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Dr. Marie Gabrielle Laguna

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Medical doctor-internist

https://www.eternusglobal.com

L-Theanine Can Relieve Anxiety and Promote Good Sleep

Nov 8, 2018

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Anxiety disorders are one of the most common mental illnesses in the whole world, affecting million of adults worldwide.

The effects of anxiety may stumble over into each gap of life, and perhaps one of the hardest costs of anxiety is the way it messes with sleep.

Treatment of anxiety problemsor at least symptom-managing methodsis now in-demand.

Mental disparities are complex, multifactorial, and unique, and the way they’re managed must replicate this intricacy.

Whether or not you have debilitating anxiety or are an ocassional worrier, there are a number of easy methods that you are able to do daily to help yourself relax.

One daily habit that you may consider is drinking tea. Tea contains a powerful ingredient called? L-theanine which can sustain you in dealing with anxiety and will help you have a better night’s sleep.

The Benefits Of L-Theanine

Apart from the calming results of the ancient ritual oftea drinking, the tea itself has some definite neurological benefits. There are many studies showing that L-theaninea soothing amino acid in tea, lowers anxiety and enhances relaxation.

L-theanine has been provento pass through the blood-brain barrier, within about half-hour of taking it, and expand alpha-wave brain production the identical brain bandwidth that occurs for the duration of deep rest and meditation.

Meditation is broadly known as a relief for nearly every mind-body ailment, and now you can gain some benefits fast while also enjoying its taste.

L-theaninehas been provento calm out brain waves by relaxing them, growing alpha waves and encouraging relaxation but not producing any drowsiness or sedation, like other anxiolytics are apt to do.

L-theanine seems to have a similar balancing-out outcome on neurotrans mittersreducing the excitatory ones such as glutamate and boosting those that inhibit excitement, such as GABA.

L-theanine advances the production of the significant inhibitory neurotransmitters within the anxiety process: GABA or gamma-aminobutyric acid, a chemical created by the brain and used as a natural supplement to bring about good sleep, reinforced mood, and relief from anxiety.

On the other hand, L-theanine has a negative effect on glutamate receptors, thereby reducing and enhancing stable levels of the essential excitatory neurotransmitter in the brain, which is glutamate.

L-theanine appears to lessen the harm of the sympathetic anxiety response.

This study has shown that L-theanine supplementation can avoid the sudden upward drive in blood pressure andlower the heart rate and salivary immunoglobulin A responses to an acute stress event.

L-theanine is available in green, black, and white teas, with green tea containing the most L-theanine. Green includes small amounts of caffeine,though it also contains healthy catechins and flavonols that offer more health-protecting advantages.

Lipoxazolidinone A: New Compound Against Drug-Resistant Bacteria

Nov 7, 2018

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Researchers from North Carolina State University have created an analog of lipoxazolidinone A, a small molecule that’s active towards drug-resistant bacteria such as methcillin resistant staphylococcus aureus (MRSA).

This molecule, a new synthetic compound, could be a treasured chemical substance for studying diverse Gram-positive infections and could have suggestions for future production.

Lipoxazolidinone A is a main product which had been isolated from bacteria dwelling in marine sediments.

It is a secondary metabolite, or a small molecule produced by the microorganism that isn’t key to its existence however is created for a secondary purpose, like protection.

When lipoxazolidinone A was at first isolated, investigators noted that it had action against Gram-positive bacteria, like MRSA.

Lipoxazolidinone A and Drug Resistance

The researchers intended to confirm these results and understand how the molecule’s structure connected to its function; briefly, they wanted to reconstruct the molecule to see what portions were in charge for its anti-microbial features and then possibly support that function.

They used new chemical tools to create lipoxazolidinone A within the lab. They had been armed to verify that its chemical composition harmonized what the initial researchers had designated, then they worked to recognize the portion of the molecule that was accountable for its role against Gram-positive microorganisms.

Their product was a compound with expanded efficiency, JJM-35.

They validated JJM-35 towards a panel of resistant and non-resistant microorganism. When recognized in opposition to MRSA in-vitro, they positioned that the synthesized molecule was more active than the natural product contrary to several bacterial strains.

Moreover, they found that the molecule was most likely to be more powerful towards tough bacterial traces than it was against nonresistant strains.

According to the investigators, anexceptional part of this work was that they documented that these molecules could function by constraining more than one biosynthetic pathways instantly or indirectly. This means that microorganisms could develop resistance to medicines developed from these molecules.

The researchers expectthat JJM-35 and comparable compounds can be used as tools to study different Gram-positive bacteria and deliver a platform for the development of a new classification of anti-infective drugs.

According to them, at this point, they have a chemical framework, a starting piece of the puzzle. All their efforts are now concerned about evaluating the locations of these molecules and their in-vivo efficacy.

They hope is that they are able to construct upon this scaffold to create medications which might be potent towards MRSA and different resistant bacteria.

Brisk Walking Can Make You Live Longer

Nov 6, 2018

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Speeding up your walking could lengthen your life, according to a study led by researchers from the University of Sydney.

Walking at a usual pace was discovered to be related with a 20% risk reduction for all-cause mortality when likened with walking at a slower rate, as brisk walking was once linked to a risk reduction of 24 percent.

A similar effect was once determined for risk of cardiovascular deaths, with a reduction of 24 percent for walking at a normal pace and 21 percent for brisk walking, as compared to walking at a slow rate.

The protecting effects of brisk walking had been additionally observed to be more recommended in older individuals. Many joggers aged 60 years or older had a 46% risk reduction in deaths from cardiovascular reasons, and brisk walkers have a 53 percent reduction.

Brisk Walking and Mortality

Relating death records with the result of 11 surveys in England and Scotland between 1994 and 2008, wherein subjects defined their walking rates, the investigators then adjusted for reasons like quantity and intensity of all physical activities done, age, sex and body mass index.

Walking rate is connected to all-cause mortality rate, but its thorough role, impartial from the whole physical activity an individual undertakes, has gotten little attention except now, according to the researchers.

While sex and body mass index did not appear to influence outcomes, walking at a normal or rapid rate is related to a vastly lessened chance of all-cause mortality and heart disease. There was no evidence to recommend that walking rate had an impact on cancer mortality.

In view of the findings, the research team is signifying that walking rate should be highlighted in public messages.

According to the researchers, setting apart the outcome of one exact side of physical exercise and working out its probable cause with the risk of premature death is tricky.

If their outcome replicates motive and results, these analyses recommend that walking rate is also a direct way for people to reinforce heart health and risk for untimely mortality — delivering an easy message for public health campaigns to advertise.

Especially in conditions when walking more isn’t practicable due to time pressures or a much less walking-friendly setting, going for brisk walking could also be an excellent substitute to get the body up, one that most people can easily contain into their lives.

Green Tea Molecule Could Prevent Heart Attacks

Nov 6, 2018

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Green Tea Molecule breaks up harmful protein plaques in blood vessels.

Green tea can be the vital thing to ending deaths from heart attacks and strokes brought about by atherosclerosis. This was according to a study published in the Journal of Organic Chemistry.

Experts from Lancaster University and the University of Leeds have exposed that a compound discovered in green tea, presently being studied for its capability to shrink amyloid plaques in the brain in Alzheimer’s disease, also breaks up and liquifiesdamaging protein plaques discovered in blood vessels.

Atherosclerosis is the assembly of fatty deposits within our arteries that may stop the flow of blood to the brain and other parts of the body. In majority of cases, a protein known as apolipoprotein A-1 (apoA-1) can form amyloid deposits, which are alike in structure to those linked to Alzheimer’s disease. These deposits build up within atherosclerotic plaques. There, they surge the size of the plaques, further restricting blood flow and may also make the plaques much less steady, growing the chance of a heart attack or stroke.

Epigallocatechin-3-gallate and Amyloid Plaques

Investigators found that epigallocatechin-3-gallate which is related to green tea, binds to the amyloid fibres of apoA-1. This alters the fibres to smaller soluble molecules that are less likely to be unsafe to blood vessels.

Now, the teamis working on discovering ways of presenting strong quantities of EGCG into the blood without having to drink enormous quantities of green tea. This could involve adjusting the chemical structure of EGCG, making it easy to be absorbed from the stomach and more resilient to metabolism, or creating new methods to provide the molecule to the plaques such as by injection.

The researchers commented that the health and wellness advantages of green tea were generally endorsed, and it has been identified for some time that EGCG can modify the assemblies of amyloid plaques related to Alzheimer’s disease. The outcomes of this study have shown that this intriguing compound would also be effective against plaques which can cause heart attacks and strokes.

They further added that our bodies are very good at breaking down EGCG so substituting your cupfor green tea is not likely to make a huge alteration with respect to your heart health. However with the help of engineering the molecule fairly, they may be capable of making new drug treatments to deal with heart attack and stroke.

The findings of these reports are very encouraging, they commented. Scientists now need to apply the great scientific tactics to seek out how we can take the molecular EGCG aspectof green tea and turn it into a functioning strategy to fight life-limiting health disorders.

Baking Soda: Can It Improve Cancer Treatments?

Nov 5, 2018

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A Ludwig cancer study has exposed a new mechanism in which cells enter a state of latency as tissues starved of oxygen end up more acidic.

The study, led by Chi Van Dang, director of the Ludwig Institute for Cancer study, has many suggestions for cancer therapy: Stable tumors are most often deprived of oxygen, and cells in such groups can be a chiefbasis of drug resistance and treatment relapses.

This present study clarifies that with acidity, cells shut off a central molecule called mTORC1 that, in normal situations, measures the accessibility of vitamins and minerals before giving cells the capacity to grow and divide.

According to the investigators, this shuts down the cell’s creation of proteins, unsettling their metabolic activities and circadian rhythms, and pushing them into aninactive state.Additionally, they have found out that this acid-mediated result may be easy to reverse — a finding that might help in cancer treatment.

Cancer Tumors, mTOR and Baking Soda

In cancer �imbedded into mice, the researchers saw mTOR activity in patterned places where there is oxygen. But when baking soda was added to the feeding water given to the mice, the whole tumor lights up with mTOR activity. The prediction is that reawakening these cells can make the tumor more sensitive to chemotherapy.

Baking soda had previously been described to enhance cancer immunotherapy by other cancer trials, though the mechanism causing this was once uncertain.

Dang’s team, together the other researchers, learned this mechanism through a complicated sequence of experiments. These studies focus on the conduct of lysosomes — a sack-like cell organelle that digests proteins. They have found out that mTOR moves when it’s competent for action.

The investigatorsdemonstrate that in acidic conditions, proteins push lysosomes carrying mTOR away from the field round the nucleus, the place where they are located. This splits mTOR from a protein required for its initiation, RHEB, which is present at that location. Missing one of its key initiation alerts, mTOR remains resting, suspending the synthesis of proteins — together with the mechanisms of the cell’s molecular clock — along with metabolic activity.

According to the researchers, cells don’t make proteins or other biomolecules when they’re not stressed. They want to be inactive and only wake up when matters return to normal.

The scientists found out that baking soda can reverse this effect. When given to mice in their drinking water, it notably counterbalanced the acidity of hypoxic patches in tumors. This sent lysosomes zipping again to the nuclear edge in cells — the place RHEB was once ready — and reestablished the activity of mTOR.

Dang and his staff additionally found that T cellactivation, which is essential to most immunotherapies, is also compromised under acidic conditions.

The discovery that baking soda might possibly support reverse this effect and render resting cancer cells prone to cancer treatment plans excites the researchers. Dang and his team now are looking into how acidity could influence immunotherapy and are additionally exploring the acid-prompted activity of cancer cells.

Sleep Loss Linked to Midnight Snacking, Weight Problems, Diabetes

Nov 4, 2018

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Midnight snacking and junk food cravings may also lead to unhealthy eating behaviors and represent a connection between lack of sleep and weight problems, according to a study from University of Arizona sleep scientists.

The study was conducted through a nationwide survey of 3,105 adults from 23 U.S. metropolitan areas. Subjects had been asked if they usually consumed a midnight snack and whether lack of sleep led them to crave junk meals. Additionally they had been asked about their sleep experience and existing health problems.

About 60 percent of subjects claimed they had midnight snacking and two-thirds stated that sleeplessness led them to crave more junk food.

The researchers discovered that junk food cravings were related with midnight snacking, which is also connected to an increased risk for diabetes. They also found that poor sleep is a foremost predictor of junk food cravings, and that junk food cravings were related to a larger possibility of subjects reporting weight problems, diabetes and different fitness issues.

According to the investigators, laboratory studies endorse that sleep deprivation can lead to junk meal cravings at night, which results in increased unhealthy snacking at nighttime, which then leads to weight gain. This linking between poor sleep, junk food cravings and unhealthy midnight snacking could portray the fact that sleep helps in metabolism control.

Sleep is more recognized as a primary aspect in health, alongside diet, claimed the researchers.� The study indicates how sleep and eating patterns are linked and work collectively to promote health.

UA sleep scientists work as interdisciplinary teams, directing studies and leading clinical trials to regulate how sleep influences memory, mental health, stress, alertness and decision-making, and the way environmental issues have an influence on sleep. Sleep and wakefulness difficulties affect an estimated 15 to 20 % of U.S. adults, according to National Institute of Health.

This research was presented at SLEEP 2018, the 32nd annual meeting of the Associated Professional Sleep SocietiesLLC (APSS), which is a joint enterprise of the American Academy of Sleep Medicine and the Sleep Research Society in Baltimore. The assembly is the world’s most popular discussion board to present and speak about today’s trends in medical sleep medication and sleep and the 24-hour cycle that influences physiology and behavior, referred to as circadian rhythm.

Carrots: Facts and Healthy Benefits

Nov 4, 2018

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Carrots were some of the vegetables scrutinized in recent studies on foods that are rich in beta-carotene and their relation to bone health. More chiefly, ingesting yellow, orange and green veggies was once assessed to find out if a higher consumption is related to higher bone mass.

Interestingly, members who ate a minimum of one serving per day of yellow, orange or green veggies had healthier bone mass than contributors who ate less than one serving per day.

Furthermore, members who ate lower than one helping per day had bone mass at a level that would put them at risk for bone-associated difficulties.

Carrots are vegetables which are often enjoyed as both uncooked and cooked forms.

While carrots can be treasured in a variety of colors,from whites and yellows to reds and purples, most of them are orange in color. As a least goal for vegetable intake from the yellow or orange types, experts recommend consuming them half a cup per day.

Optimal intake would be one cup per day, along with greens, potatoes, squash, and yellow corn which can contribute to your everyday nutrient requirements.

Health Benefits

Carrots are well-recognized for their rich supply of this antioxidant nutrient that was once named for them: beta-carotene. Nonetheless, these delicious root veggies are the best sources of beta-carotene and other vitamins and minerals.

All varieties of carrots have valuable amounts of antioxidant vitamins and minerals such as vitamin C and beta-carotene.

In many varieties of carrots, beta-carotene is essentially the most abundant antioxidant nutrient, which is responsible for over 95% of all carotenoids in many carrot types.

Different carotenoids that are typically present in carrots comprise of alpha-carotene and lutein. The most common antioxidant nutrients in carrots are as follows:

Carotenoids
Alpha-carotene
Beta-carotene
Lutein
Hydroxycinnamic acids
Caffeic acid
Coumaric acid
Ferulic acid
Anthocyanins
Cyanidins
Malvidins

In a study from the Netherlands, subjects had been followed for a period of 10 years and their meal plans were examined for fruit and vegetable consumption in four color categories: green, orange or yellow, red or purple, and white.

Among these four-color classes, it was foods with deeper colors of orange and yellow that had been determined to be essentially the most protecting against cardiovascular diseases (CVD).

The capability of carrots to provide cancer-protecting advantages has been an active study on this root vegetable. Of special interest on this field are substances found in the carrot referred to as polyacetylenes.

Carrots have the capability to take their fatty acids and convert them into molecules called polyacetylenes. These polyacetylenes include molecules like falcarinol and falcarindiol. Polyacetylenes furnish carrots with defense from microorganisms, including fungi and bacteria, and they have also have proven anti-cancer effects.

There are also some studies which have some that greater carrot consumption may lead to lower glaucoma rates than people with little carrot intake. One phytonutrient in carrots, geranyl acetate, is a substance that is known to give rise to cataract protection.

Lower Belly Fat: How to Burn It Effectively

Nov 3, 2018

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Lower belly fat is something that most of us handle, and a rapid solution to get rid of it would be good. However, there’s no riskless and fast way to reducing lower belly fats. Doing many crunches everyday will not always yield the best results that you want for your abdomen.

Even though there’s no speedy method to burn lower belly fat, both diet and exercise play a central function in weight loss, which is the most effective way to get rid of belly fat. Here are some of the best tips for weight reduction, thereby getting rid of those unsightly fats from our abdomen.

Choose the Right Carbs

You can consume carbs and nonetheless lose belly fat. The varieties of carbs that you eat are what’s important. Processed and white carbs like certain breads, pastas, and baked items are processed rapidly in our bodies as sugar. When there’s an excessive amount of sugar in our bodies, we retain them as fat within the body, particularly in the belly.

Consume Whole Foods

Whole foods are the varieties of food that come from the earth, like fruits, veggies, seeds, nuts, and beans. Consuming whole foods from nature, as an alternative to fast-food found in packages or cans, is, without doubt, one of best things you can do for yourself and your loved ones.

Whole foods are unprocessed and not exposed to chemical substances and preservatives, unlike boxed and processed foods that may be bought at many grocery retailers. Whole foods additionally tend to have a lot of health advantages. Eating whole foods will not only eliminate the undesirable belly fat but will additionally supply your body with the essential vitamins and minerals it desires to function efficiently.

Consume Fiber

Fiber can be observed in several foods such as grains, fruits, vegetables, and legumes. Fiber not only helps with urge for food control, but it also stabilizes blood sugar, and improves gastrointestinal health, and feeds good bacteria in our microbiome. Feeding the good microorganisms in our bodies can help as lose weight, while processed meals with little to no dietary value could make us gain weight.

Eat more soluble fiber from oats, barley, peas, carrots, beans, apples, citrus fruits, and psyllium.?Soluble fiber will lower bad cholesterol and get rid of them from your digestive system, to decrease the risk of heart disorder while you also lose belly fat.

Reduce the Sugar

The quantity of sugar we consume in a day is rather baffling, therefore checking labels is important. Sugar will also be lurking from crackers and salsa to bread and drinks. By cutting on our sugar consumption, we have� less sugar in the body that will get saved as fat.

Exercise

Exercise is a good way to lose belly fat, together with eating a healthy diet. Find anything you enjoy doing, whether it’s walking, running, climbing, or yoga. You can additionally try weight coaching, which can support you shed some lower belly fat fast.

When Does Drinking Become a Problem?

Jul 31, 2018

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About 2 billion people across the world consume alcoholic drinks.� Drinking becomes a problem when over-consumed. Consumption can harm health as well as social relationship, but the nature and the severity of the effects depend on both the amount of alcohol consumed over time, and the pattern of drinking.

Some people have been heavy drinkers for many years. But, over time, the same amount of alcohol packs a more powerful punch. Other people develop a drinking problem later in life. Sometimes this is a result of major life changes like death of dear friends or a loved one, moving to a new home, or failing health.

These kinds of changes can cause loneliness, boredom, anxiety, or depression. In fact, depression in older adults often goes along with drinking too much.

One drink is equal to one of the following:

One 12-ounce can or bottle of regular beer, ale, or wine cooler
One 8- or 9-ounce can or bottle of malt liquor
One 5-ounce glass of red or white wine
One 1.5-ounce shot glass of distilled spirits like gin, rum, tequila, vodka, or whiskey. The label on the bottle will say 80 proof or less.

It is helpful to understand the “standard” drink sizes in order to follow health guidelines. However, it also is important to keep in mind that drinks may be stronger than you think they are if the actual serving sizes are larger than the standard sizes.

Reasons to stop drinking. Check off any reasons that sounds true for you.

I want to be healthy by keeping my high blood sugar under (diabetes) control.
I want to lower my blood pressure.
I want to keep my liver working right.
I don’t want to hurt anyone by driving after I’ve been drinking.
I don’t want to fall and hurt myself.
I want to stop feeling embarrassed about how I act when drinking.
I want to live longer.
I really wanted to change for the better.

Making change in your drinking habits can be hard. If you don't reach your goal for the first time, don’t give up!

Written by: Vina Benitez, Eternus Global

What’s The Connection Between Hearing And Cognitive Health?

Jul 30, 2018

2002

The connection between hearing and cognitive health is that people with hearing loss�are more likely to avoid social situations, which may impact both physical activity and emotional well being, any of which may mediate the relationship between hearing ability and brain health.Hearing loss occurs in approximately one in three people aged 65 and above. It is one of the most common conditions affecting older adults. Several studies have indicated that there is a connection between hearing loss and brain function decline.

Maintain that your brain always stays stimulated. According to research, this is the most important thing we can do to maintain our brains as we age to stay mentally engaged. We can also do it through an active social life with friends, family and business associates. Healthy hearing is a key part of staying involved with people you love and the world.

Luckily, hearing aids can help with this problem.

In one study, researchers identified nine risk factors for developing dementia: less childhood education, hypertension, anxiety, obesity, smoking, depression, physical inactivity, social isolation, diabetes, and, you guessed it right- hearing impairment

Although the brain becomes smaller with age, the shrinkage seems to be fast-tracked in older adults with hearing loss.

Do not ignore hearing loss, and do not delay getting the treatment you need. Take it from someone who knows what he's talking about. If hearing loss is potentially contributing to these differences we're seeing on MRI, you may want to treat it before these brain structural changes take place.

Dealing with cognitive health

It is important for people with hearing loss to take necessary actions and get the treatment they need.
Wear hearing aid device

Hearing Impairment

This is a general term which covers both young age and old aged people having hearing difficulties.

Hard of Hearing

Those whom the sense of hearing although defective is functional with or without hearing aid

Deaf

Those whom the sense of hearing is non functional for the ordinary purposes of life

When something bad happens about your hearing, you have three choices; you can let it define you, let it destroy you, or you can let it strengthen you.

Written by: Vina Benitez, Eternus Global

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