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Dr. Marie Gabrielle Laguna

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Medical doctor-internist

1422

Early Colorectal Cancer Screening Can Benefit Overall HealthColorectal cancer, also referred to as colon cancer or bowel cancer includes cancerous growths within the colon, rectum and appendix.

It’s the third most common tumor and the second reason for death among cancers in the Western countries.

Many colorectal cancers come from adenomatous polyps within the colon.

These mushroom-like growths are typically benign; however, some could become cancerous over time.

Most of the time, the diagnosis of localized colon cancer is through colonoscopy.

New Guidelines for Colorectal Cancer

New guidelines created by the American Cancer Society (ACS) propose screening for colorectal cancer for high-risk adults at age 45, five years earlier than the past recommendation.

The recommendations are created somewhat with respect to an analysis that found an increased occurrence of colorectal cancers within young adults.

Among adults younger than 55 years, there is a 51% expansion in the occurrence of colorectal tumors from the years 1994 to 2014 and a 11 % expansion in deaths from 2005 to 2015.

The investigators said that colorectal cancer frequency has declined consistently during the recent two decades in individuals who are 55 years and older, because of screening that resulted in the removal of polyps.

A present assessment found that adults who were born around 1990 have double the danger of colon cancers and four times the risk of rectal cancer when contrasted with adults who were conceived around 1950, who have the most reduced risk.

Studies suggest that the enhanced hazard for younger individuals will remain as they age.

Colorectal Cancer

Colorectal malignancy is the fourth most common cancer. It’s the second reason for cancer deaths. When identified and dealt with early, the five-year survival rate is almost 70%.

As indicated by the researchers, the alternatives for colorectal cancer screening are fecal immunochemical test yearly; extra-sensitive guaiac-based fecal occult blood test every year; multitarget stool DNA testing every three years; colonoscopy at regular intervals; computed tomography colonoscopy every five years; and flexible sigmoidoscopy every five years.

They added that positive outcomes on non-colonoscopy screening exams should be followed up with colonoscopy.

The guideline team additionally had new strategies to encourage discussions amongst clinicians and patients to enable patients to choose which test is good for them.

Given the confirmation that adults vary in their test inclinations, the specialists trust that screening charges could be increased by underwriting numerous tests without preference.

Folks should have a dialog with their doctors to make a decision on which form of screening is the best for them.

1709

3D Brain Model Can Give Health Insights in The Palm of Your HandA new 3D brain model printing technique allows for faster, better, and more cost-effective models of patient-targeted clinical knowledge for study and diagnosis.

Consider the possibility that you could keep up your very own physical brain model in your palms, which is exactly accurate to every fold.

This was true for Steven Keating, Ph.D., who had a baseball-sized tumor expelled from his cerebrum at age 26 while he was a graduate student in the MIT Media Lab’s Mediated group.

Inquisitive to look at how his mind functioned when the tumor was expelled, and with the objective of translating his diagnosis and pharmaceutical alternatives, Keating accumulated his clinical information and began 3D printing his MRI and CT scans, yet was disappointed that present methodologies had been tedious, lumbering, and neglected to unveil vital components of value.

3D Printing for the Body

Keating at that point related to his group’s teammates, including those from the Wyss Institute at Harvard College, who have been investigating another procedure of 3D printing some biological samples.

A member of the group said that they didn’t know how to utilize their innovation in human life systems until Keating came to them and gave them information.

The result of this cooperation offered another method that enables images from MRI, CT, and many medical scans to be easily and quickly adjusted into body parts with unmistakable components.

One of the associates commented that this makes focused 3D-printed clinical models with a small amount of the work required than the past, accordingly, making 3D printing more open to the clinical field as a gadget for research and analysis.

Imaging tests like MRI and CT scans deliver high-precision pictures as a progression of cuts that reveal the fundamental structures inside the human body.

Thus, they are an invaluable resource for evaluating and diagnosing scientific theories.

3D Printing and Medical Imaging

Most 3D printers construct physical things in a layer-by layer framework, so feeding them layers of medical pictures to make an unrivaled structure is a conspicuous collaboration between the two connected sciences.

In any case, there is a problem: MRI and CT scans create pictures with so much components that the article of interest should be separated from surrounding tissue and changed into networks keeping in mind the end goal to be printed.

This is executed through a very time-consuming method known as segmentation, in which a radiologist manually traces the desired object on each single image slice, which usually contains hundreds of images in a single sample, or an automated thresholding process wherein a computer quickly converts areas that incorporate grayscale pixels into either stable black or stable white pixels, centered on a shade of grey that is chosen to be the threshold between black and white.

In any case, therapeutic imaging consolidates objects which are sporadically formed and needs clear, all around borders; in this way, auto-thresholding or even manual division overstates the measurements of a feature washes out important details.

The new process described by the authors offers clinical specialists a speedy and highly accurate procedure for converting difficult pictures into a format that can be 3D printed easily.

The key lies in printing with dithered bitmaps, a computerized document design in which every pixel of a grayscale picture is changed over into a progression of high contrast pixels, and the thickness of the dark pixels is the thing that characterizes the uncommon shades of gray as opposed to the pixels themselves in different hues.

The scientists trust that their approach will help make 3D printing a more practical tool for tests and judgments, patient instruction, and investigation of the human body.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

1663

Multivitamin Supplements: Are They Really Beneficial to The Body?Probably the most common multivitamin supplements provide no health advantages or damage, according to a study done by researchers at St. Michael’s Hospital and the University of Toronto.

Published within the Journal of the American College of Cardiology, the systematic review of present information and single randomized controlled trials published in English from January 2012 to October 2017 have revealed that multivitamins, vitamin D, calcium and vitamin C, which are the most common dietary supplements, showed no benefits in terms of prevention of cardiovascular disease, heart attacks, stroke or premature deaths.

Usually, multivitamin supplements are taken to add to vitamins and minerals to food.

Multivitamins Study

The analysts asserted that they were stunned to discover some positive results of the most well-known multivitamin supplements that individuals use.

Their appraisals found that if you wish to utilize multivitamins, vitamin D, calcium or vitamin C, it does no harm to the body, however there is no evident advantages either.

One investigation uncovered that B-vitamins with folic acid may decrease cardiovascular disease and stroke. Then, niacin and antioxidants demonstrated little results that would diminish a raised danger of death from any reason.

Vitamin Requirements

These discoveries suggest that individuals ought to know about the supplements they’re taking and ensure they’re essential to the unique nourishment or mineral insufficiencies they have, as per the advice of their doctor.

The team reviewed supplement studies that integrated A, B1, B2, B3 or niacin, B6, B9 or folic acid, C, D and E; and beta-carotene; calcium; iron; zinc; magnesium; and selenium.

The term ‘multivitamin’ on this study was utilized to portray dietary and multivitamin supplements that incorporate most vitamins and minerals, that are taken to supplement general nutrition.

In the absence of large positive data aside from folic acid’s effects of reduced risk of stroke and heart diseases, the investigators said it is most helpful to rely on a healthy weight loss program to get your fill of vitamins and minerals.

The investigators add that to this point, no investigation on supplements has demonstrated an option that is superior to anything that healthy servings of veggies, fruits and nuts.

1854

Influenza A Virus: Key Molecule for Flu Infections Identified After much research, a group has discovered the main receptor molecule that upgrades flu to form into an endemic, conveying a new focus for flu medicines.

Viral infections start when a virus molecule appends to a receptor molecule outwardly of a host cell.

The infection molecule at that point seizes cell machinery to enter the cell and reproduce itself, building up the infection.

The key receptor molecule for the influenza A virus has remained unidentified regardless of many years of research.

Calcium Ions and Influenza Infections

An investigation led by Professor Yusuke Ohba of Hokkaido University has affirmed that adjustments in calcium ions in cells play a fundamental role in flu infections.

This study, published in the journal Cell Host & Microbe, the team has learned that the calcium? Channel, a transmembrane protein that makes it possible for calcium? To maneuver throughout the cell membrane, is the important receptor molecule for influenza A virus infections.

Also, treating human cells with calcium channel blockers that are utilized as hypertension drugs, significantly suppressed influenza A infections.

In tests utilizing cultured human cells, the group found that influenza A attaches to the calcium channels on the cell’s surface to trigger an inflow of calcium, which is soon followed by passage of the virus and subsequent infection.

Flattening calcium channels inhibited influenza A virus-induced calcium inflow and virus entry.

They likewise knew that sialic acid on the calcium channel is vital for the virus to attach.

At long last, the group tried calcium channel blockers on influenza A infection utilizing mice.

When they treated the animals with calcium channel blockers intranasally, a large and dose-based reduction within the number of replicated viruses was discovered.

At the point when the creatures had been treated with greater amounts of influenza A, calcium channel blockers immeasurably increased survival and permitted weight recovery of the survivors while the untreated ones died within five days.

According to the researchers, there were cases when the suppressive result of calcium channel blockers on influenza A virus infections was like that of a current anti-flu drug. They anticipate that the interplay between influenza A virus and the calcium channel would be a new and important target for future drug development.

1701

Daily Calorie Requirements: How to Calculate ThemTo shed extra pounds, reap muscle, or maintain your present weight, you should comprehend what number of calories you should be eating in a day.

Not eating enough or eating too much can lead to unwanted weight gain or weight loss, which is why you must know the amount of energy you will be needing in a day.

To better help you reach your fitness pursuits, here is a simple method to calculate your day-to-day caloric intake.

First, you’re going to need to know your weight in kilos. Next, check what your purpose is: weight loss, weight maintenance, or weight gain. From there, pattern it to your goal. The final step is to multiply how so much you weigh by the two numbers given, which can be decided by your purpose and activity levels.

A calorie is an energy unit that your body uses to function every day.

The energy that you devour from foods offers your body some energy.

Everybody’s day by day caloric needs are based on age, height, weight, body mass, gender and action. When you know the best approach to figure your everyday calorie needs, you could outline an eating plan that could help meet your health objectives.

How to Calculate Your Total Calorie Needs

Use an online calculator.

You can figure out your general calorie needs with the wide assortment of accessible online health calculators.

These can be more straightforward to use and considerably less intricate than doing the calculations yourself.

You can find many calculators from many health sites. Ensure you are choosing a dependable website and don’t utilize calculators from blogs or other non-official sites.

Many of those calculators work in the same way. You’ll enter your height, weight, sex, age and physical activity. Have these facts ready while you calculate your requirements.

1. Know your basal metabolic rate or BMR

Your BMR is the number of calories your body needs for proper functioning.  It’s your metabolic rate or the number of calories your body consumes when at rest.

Your body wants a certain number of calories to function normally.

The BMR equation for the normal female is: (4.7 x your stature in inches) + (4.35 x your weight in pounds) – (4.7 x your age in years). Add 655 to the total basal metabolic rate.

The BMR equation for the average male is: (12.7 x your height in inches) + (6.23 x your weight in pounds) – (6.8 x your age in years).

Add 66 to the BMR's total.

You will be using your BMR in the Harris Benedict equation to discover what number of calories you need.

2. Calculate your total energy consumption with the Harris Benedict Equation.

The Harris Benedict Equation lets you figure out what number of calories you consume every day by increasing your BMR with your normal physical activity.

  1. Multiply your BMR with your activity levels. This will come up with an accurate result of your daily calorie intake.

In case you’re inactive or having zero exercise, multiple your BMR by 1.2.

In the event that you are having light activity or exercising around 1-to-3 days every week, you should multiply your BMR by 1.375.

In the event that you are moderately as well as play sports 3 to 5 days, multiply your BMR by 1.55.

In the event that you are taking part in strenuous activities or hard exercise for 6 to 7 days per week, multiple your BMR by 1.725.

In the event that you are very active with physically difficult exercise, for example, twice a day workouts, multiply your BMR by 1.9.

4. Consider body fats percentage

The more muscular you are or the less body fat you have, the greater will be your daily calorie requirements.

In the event that you are an athlete or have low amounts of body fat, you may need a bigger number of calories than usually required.

Lean muscle consumes more calories than fats.

Eating a small quantity may additionally help you attain more suitable calorie goals.

Also, be aware that overweight or obese humans may additionally overestimate daily calories with the Harris Benedict method.

1709

Transdermal Estradiol Progesterone Can Improve Cognitive Brain FunctionAnother investigation has shown that there are brain benefits of transdermal estradiol blended with an oral progesterone for postmenopausal women.

Hormones affect a great deal that goes ahead in a woman’s body, from reproductive functioning and sexual drive to weight gain and general psychological wellness.

Another investigation indicates how, in the correct dose and blend, hormones may enhance brain functioning in postmenopausal females as they age.

 

The results are published in Menopause, the journal of The North American Menopause Society (NAMS).

Estradiol Progesterone and Brain Function

It does not shock anyone that intellectual capacity decreases as we age.

We experience memory decline in a multitude of ways, such as forgetting a grocery list every now and then.

Mild cognitive impairment is characterized as that middle stage between aging and dementia.

Individuals with mild cognitive impairment have more danger of advancing to Alzheimer’s disease or other dementia, with about 20% of this population traversing from mild cognitive impairment to a more extreme degree every year.

To this point, no pharmacologic cure has been deemed to be effective in managing mild cognitive impairment.

Hormones and Mild Cognitive Impairment

The investigation is about the aftereffects of a Korean study that involves the consequence of hormone treatment on psychological capacity.

The study monitored postmenopausal women who were diagnosed with mild cognitive impairment and were taking donepezil over a 24-month period. The investigators confirmed that cognitive scan ratings for the women who received hormones enormously multiplied during that point.

Even though the group was small, the examination presents promising results, exhibiting that the blend of transdermalestradiol and an oral progesterone can back off cognitive decline. That is the first study to survey the aftereffects of hormone treatment on mild cognitive impairment.

This empowering, little pilot study recommends a conceivable advantage of hormone treatment when given to females who have mild cognitive impairment who are likewise taking donepezil, a cholinesterase inhibitor.

More cognition is one of the three key measures in those women who are using estradiol gel in addition to an oral micronized progesterone compared those taking placebo. More studies are needed to survey the results of hormone treatment use before the full start of Alzheimer disease.

Baking Soda Can Help Fight Autoimmune DiseaseBaking soda may help in in reducing inflammation that is brought about by autoimmune disease such as rheumatoid arthritis, researchers say.

They have one of the first evidence of how the inexpensive, over-the-counter antacids can urge our spleen to make an anti-inflammatory system that would benefit inflammatory diseases, according to a study that is found in the Journal of Immunology.

They have demonstrated that when rats or healthy people drink baking soda, or sodium bicarbonate, it triggers the gut to make more acid to process meals and for mesothelial cells on the spleen to tell the essential organ that they should mount a defensive immune reaction.

How Baking Soda Fights Autoimmune Disease

Mesothelial cells line body organs, like the one that includes our gastrointestinal tract, thus they additionally cover the outside of our organs to keep them from rubbing together.

About a decade in the past, it was known that these cells additionally furnish a layer of protection.

They have little fingers, known as microvilli, that sense the environment, and alert the other organs that there is an invader in the body and that an immune reaction is required.

By taking baking soda, the spleen, which belongs to the immune system, acts like a major blood channel and is the place where white blood cells, like macrophages, are put away.

The spleen moves according to the immune response.

This response that is bolstered by the substance acetylcholine, seems to advance a display that moves against infection.

M1 and M2

Inside the spleen, the blood and the kidneys, after taking in water with baking soda for two weeks, immune cells like macrophages, transformed from those that promote disease, alluded to as M1, to those that diminish it, known as M2.

Macrophages, best identified for their ability to eat garbage within the body, are early arrivers in a call for an immune response.

The kidneys are involved in balancing important chemicals like acid, potassium and sodium.

With kidney problems, there’s impaired kidney functioning and most likely one of the following issues is the blood acidity. This can prompt increased dangers of cardiovascular problems and osteoporosis.

This basically implies that a daily dose of baking soda does not simply diminish acridity yet can slow down the progress of kidney problems, and it can even be considered as a treatment.

This is the point at which the anti-inflammatory effects started to unfurl as the specialists saw decreased quantities of M1s and enhanced M2s of their kidney disease model after taking in baking soda.

After the specialists looked at a rodent model without kidney disease, they saw a similar reaction. Along these lines, the researchers examined healthy people who drank baking soda with a bottle of water and they observed the same effects.

The researchers hope that ingesting baking soda can someday produce similar results for persons with autoimmune disorder.

Dark Chocolate Can Reduce Stress and InflammationNew research demonstrates there might be health benefits to eating a lot of dark chocolate.

Discoveries from two cases introduced in the Experimental Biology 2018 Annual Meeting in San Diego demonstrate that devouring dark chocolate that contains cacao (around 70% cacao, 30% sugar) affects feelings of anxiety, aggravation, mood, memory and immune resistance.

While it is well identified that cacao is a fundamental supply of flavonoids, this is the first time the influence has been studied in humans to check the way it can help cognitive, endocrine and cardiovascular health.

Effects of Chocolate on The Brain

The researchers remarked that for years, they have seen an effect of dark chocolate on neurological capabilities based on sugar content. This means that the more sugar, the better. This is the first time that they have seen the effect of cacao in doses as small as an ordinary-sized chocolate bar in people for short periods of time.

These reports just demonstrate that the greater the amount of cacao, the more positive its impact on brain health, memory, conduct, immune resistance and others.

The flavonoids found in cacao are potent cell reinforcements and calming substances, with distinguished systems that are beneficial for the brain and the heart.

Studies

The studies are as follows:

  1. Dark Chocolate (70% Cacao) Affects Human Gene Expression: Cacao Regulates Cell Immune Response, Neural Signaling, and Sensory Perception

This pilot study analyzed the effects of 70 percent cacao chocolate on human immune and dendritic cell functions, centered around cytokines. The investigation discovered that cacao upregulates several intracellular pathways in T-cell activation, cell response and neural signaling and sensory functions.

  1. Dark Chocolate (70% Natural and Organic Cacao) Raises Acute and Persistent EEG Spectral Density Response of Gamma Frequency (25-40Hz) for Brain Health: Enhancement of Neuroplasticity, Neural Synchrony, Cognitive Processing, Thought, Memory and Mindfulness Meditation

This study assessed the electroencephalography (EEG) response to drinking 48 g of dark chocolate (70% cacao) after an acute interval of time (30 minutes) and after a chronic interval of time (120 mins), on modulating brain frequencies 0-40Hz, needing gamma frequency (25-40Hz).

The results demonstrate that 70 percent cacao improves neuroplasticity for brain functioning.

The researchers mentioned that the studies require additional investigation, to assess the value of these effects for immune cells and the brain in greater populations.

Extra research is being done to know the ways that cacao affects brain-behavior relationships.

1753

Growth Hormone May Furnish New Hope for Stroke SurvivorsLess fatigue and restoration of cognitive functions such as learning and memory. These are the outcomes of growth hormone treatment after a stroke, a study done in mice published in the journal Strokesuggests.

According to the researchers, his work can pave the best way for clinical studies using human growth hormone as treatment used within the rehabilitation phase after a stroke.

Treatment and rehabilitation after a stroke is a goal, both for the victims and those around them.

Recuperation commonly involves a long and tricky process to restore speech, memory, the potential to pay attention and more. Fear, anxiety and severe fatigue are also common among people who have survived a stroke.

Growth Hormone and Stroke Study

The present study is created on research carried out in partnership between the Universities of Gothenburg and Newcastle. The results show a link between growth hormone and increased cognition after a stroke because the of feasible mechanisms which have been shown.

The truth that growth hormone conventionally has constructive effects on cognition after brain damage has been observed in previous studies.

Then again, this is the first time the consequences of growth hormone are being verified after a stroke, and the conclusions are considered as being very positive.

The mice in the study, all with triggered strokes, had been preserved with both an infusion of growth hormone or with placebo for 4 weeks. Within the last week of treatment, they have been observed personally in separate cages with touch displays.

The animals had been exposed to visual symbols in different blends where a proper pressure with a paw on the screen gave a reward within a sugar solution.

The mice that acquired the growth hormone did well in 8 out of 10 cases. After conclusion of the experiments, researchers additionally analyzed a number of development factors and biomarkers within the injured brain.

According to the researchers, the growth hormone advances cognition after a stroke when associated with controls. If this finding holds true for humans, it may lead to a great leap forward with detection of medications that permits rehabilitation and quality of life after a stroke.

Growth hormone was tested in brain plasticity before. The medication give rise to higher levels of markers that led to the formation of new blood vessels, repair of nerve damage and decreased loss of brain tissue compared to controls.

Now researchers hope to get more funding to scientific trials and examine whether growth hormone medication can be successful if some time has passed after the onset of a stroke.

1685

Vitamin A - Basic Facts and Health Benefits

The term “vitamin A” makes it sound like there may be one unique nutrient known as Vitamin A” but that isn’t true. Vitamin A is a vast group of associated nutrients.

Every vitamin and mineral present us with wellness benefits, but these advantages are also one-of-a-kind and so they could also be supplied in specific approaches.Here are some facts about Vitamin A.

Types

There are two basic types of vitamin A: retinoids, which are discovered in animal foods and carotenoids, which are found in plant sources. These two types aren’t simply chemically exceptional – they also furnish us with unique varieties of health benefits.

There are some thorough advantages of vitamin A that can most effective be received from the retinoid varieties of the vitamin. These retinoid varieties can also be important with respect to pregnancy and childbirth, childhood development, night vision, red blood cell production, and resistance to infectious diseases. Almost every of us need retinoid forms of vitamin A.

Just like the retinoid forms of vitamin A, the carotenoid varieties also provide us with health benefits. Most carotenoid variations of vitamin A are antioxidant and anti-inflammatory nutrients. Mostly specific carotenoids have a specific role to play in our wellbeing. For instance, the only carotenoids inside the retina of the human eye are lutein and zeaxanthin. Spinach, kale, and Swiss chard are examples of vegetables that are rich in lutein and zeaxanthin.

How Does Vitamin A Help Health?

While vitamin A is greatly known for its major role in vision, the retinoid types also participate in biological events regarding the immune system, inflammation, growth of tissues, reproduction, bone development, production of red blood cells, and creation of spermatozoa (male reproductive cells).

In food, the retinoid forms of vitamin A show up as retinyl esters. The body is often able to convert these retinyl esters into active forms of vitamin A together with retinol, retinal, and retinoic acid.

Retinal, which is the aldehyde form of Vitamin A, contributesto the synthesis of rhodopsin, and within the arrangement of chemical reactions that creates visual excitation, which is prompted by striking the rod cells. The other three pigments known as iodopsins, are located within the cone cells of the retina and are in charge for daytime vision.

Vitamin A performs a key function in support of immune processes. Our digestive tract can get exposed every day to potentially undesirable components like pesticides in meals, as well as undesirable micro-organisms. Our immune system is designed to support us from being harmed by these processes.

Vitamin A is required for cell growth and development. Even though the mechanisms through which vitamin A promotes cell growth and development are not fully understood, it is recognized that retinoic acid is necessary for the synthesis of many glycoproteins, which control cell adhesion, cell development, and cell differentiation.

Other Functions for Vitamin A

Vitamin A is vital for reproductive processes in both women and men and plays a role in bone metabolism. Vitamin A is known to be required for the creation of sperm or spermatogenesis.

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