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Dr. Marie Gabrielle Laguna

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Medical doctor-internist

https://www.eternusglobal.com

Soy Lecithin-NSAID Combo Drug Protects Against Cancer with Few Side Effects

Jan 10, 2019

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At the point when researchers at the University of Texas Health Science Center at Houston (UTHealth) utilized a substance found in soybeans with a non-steroidal anti-inflammatory drug (NSAID), they broadened its anticancer properties and decreased its side effects.

Results of the preclinical investigation of phosphatidylcholine, regularly known as lecithin, has been published inside the journal Oncology Letters.

The outcomes promote the use of NSAIDs with phosphatidylcholine to prevent and treat colorectal cancer.

The NSAID indomethacin identified with phosphatidylcholine was once considered in a careful assessment with three different NSAIDs (one is aspirin).

Soy Lecithin-NSAID Combination

According to the results, the combination offered advanced colorectal cancer treatment with less gastrointestinal bleeding.

The examination was done in a mouse model and in research facility tests.

Colorectal cancer is the third fundamental driver of cancer deaths in the United States and is said to claim 50,630 lives this year.

NSAIDs and Colorectal Cancer

NSAIDs work by diminishing the elements that lead to inflammation, pain and fever. They are utilized to avert heart disease and reduce joint pain.

NSAIDs, mainly aspirin, also works against colorectal cancer.

The scientists asserted that numerous cancers are based on inflammation

The anti-inflammatory medicines even have the potential for cancer treatment.

However, when taken daily for months to years, NSAIDs can bring about issues. The gastrointestinal harm is worse for non-aspirin NSAIDs like indomethacin.

The specialists remarked that this is a front line preclinical investigation on the utilization of phosphatidylcholine to alleviate the reactions of NSAIDs and protect against various cancers.

Cell Aging: 10 Foods That Makes You Look and Feel Younger

Jan 10, 2019

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The body has its own way of eliminating toxins and free radicals in cell aging.

This process is known as autophagy, which means the breakdown of old cells and waste products by the body's own cells.

However, as we become older, this system becomes less effective and harm ensues.

That development eventually backs off cell function and can bring about slower metabolism, lessened collagen and elastin repair, and reduced organ functioning.

The good news is, you may get your cells to repair themselves again! It?s a lot simple and more enjoyable than you think.

All you must do is eat! There are compounds in some foods that help in cell repair.

And the fine thing is that are already in your kitchen! Listed below are the 10 foods for looking and feeling younger:

1. Chocolate

This autophagy-actuating polyphenol controls life span and metabolism.

It could prompt free radical excretion, while speeding fat breakdown, and helping keep off food cravings.

Consume chocolate with at least 70 percent “cocoa solids” on the label as these have more polyphenols than the ones with lo percentages.

2. Eggs

Eggs have a compound called sphingolipids that aides in autophagy.

Like in a wall, sphingolipids resemble mortar, the sticky substance that holds the blocks together. Since the wall ages, the mortar can separate, making the blocks come apart and the entire structure to lose its stability.

You can keep your mortar solid by eating sphingolipid-rich foods.

Doing such will change your skin, making it more full, plumper, and smoother.

Sphingolipids also help control neurotransmitters, leading to healthy brain function, better moods, better selection-making, increased cognitive thinking, and enhanced memory.

3. Salmon

Salmon contains omega-3 fatty acids that can suppress inflammation and stimulate autophagy in some cells. Additionally, omega-3s can lead to better heart health and can protect your brain cells.

4. Cauliflower

Cauliflower has a sulfur-containing compound known as sulforaphanes that start autophagy by boosting ways that debase old, unusual proteins.

It additionally carries on as a cancer prevention agent, casting off free radicals from cells.

5. Mango

Mangoes have 122 milligrams of autophagy-enhancing vitamin C per fruit.

They are additionally a rich source of zeaxanthin, a cell antioxidant that helps keep your eyes healthy by sifting through blue light rays that add to macular degeneration.

6. Pork

Pork contains vitamin D that helps control your autophagy by enhancing cell to cell communication.

Plus, Vitamin D is important in immune system regulation.

Vitamin D may also stimulate the production of vitamin E, which also promotes autophagy and is a cancer-combating antioxidant.

Grass-fed pigs have pork which is more likely to be free of hormones and antibiotics.

7. Avocado

Avocado is among the best autophagy-advancing foods. It is rich in vitamin E, vitamin K, and healthy fats. Vitamin E is a cell antioxidant �that shields the body from free radicals.

8. Cheese

Cheese is rich in spermidine, a traditional polyamine found in plant and human cells.

In humans, levels of spermidine get reduced as we age, which is important, considering that they directly engage with DNA and activate genes that regulate autophagy.?

Some studies show that spermidine can help increase life span and reverse age-related heart problems, and it is also proven to boost memory.

9. Legumes

Legumes are full of saponins, plant compounds that have cleansing properties that froth when shaken with water.

They enhance autophagy by boosting the immune system. They can likewise bring down cholesterol and help control glucose levels.

This is critical in autophagy, as glucose triggers insulin secretion, which turns on genes that stop autophagy.

10. Sauerkraut

Sauerkraut is full of in probiotics, since there are bacteria found in fermented food. It could help with absorption by sending cell signals that start autophagy and prevent cell damage.

Cancer Metastasis: New Cell Mechanism Discovered by Scientists

Jan 9, 2019

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Researchers on the Virginia Tech Carilion Research Institute have investigated another facet into how cells change their correspondence with each other amid growth, wound treatment, and the spread of tumors.

The experts their outcomes in Molecular Biology of the Cell, a journal distributed by the American Society for Cell Biology.

As per the scientists, they have picked up another knowledge as to how a cell can progressively tweak its blend of proteins from existing genetic instructions. This idea of modulating is new to the field.

When body tissues develop or recuperate, its external layer of epithelial cells goes up against attributes that allow cells to emigrate, change their size and properties, and act as various cell assortments, particularly multipotent mesenchymal cells which may be good for making repairs.

The procedure is called the epithelial mesenchymal transition, or EMT.

Epithelial Mesenchymal Transition

As per the scientist, EMT is additionally enacted in different disease forms, similar to fibrosis and cancer metastasis. In any case, these cells are exceptionally easy to control.

have built a powerful gadget to learn this strategy to reveal insights into cancer metastasis.

They found that cancer cells exchange their correspondence to be more obtrusive, to partitioned, and to scatter all through the body.

They commented that experts may even use their approaches to fully grasp cell responses to injury and disorders in other pathologies, like heart disease.

Connexin 43

The specialists considered correspondence between cardiovascular cells, with an attention on the capacity of a protein called connexin 43. Connexins are found in each tissue of the body.

At the point when six connexin 43 proteins meet up, they create channels known as gap junctions through which cells interact.

Before, individuals have noticed that the more connexin proteins in the cell are, the more gap junctions the cell would make, subsequently encouraging cell correspondence.

Like a few proteins, Connexin 43 is orchestrated from the message encoded in RNA that can render the DNA code.

The RNA may likewise encode for littler parts or pieces of connexins 20k, that prompts gap junction development.

The specialists utilized the VTCRI’s high resolution microscope to assess individual molecules and to know the connexins inside the cells.

They found that entire connexins had been captured inside the cell’s Golgi apparatus, which goes about as a bundling plant for proteins going to the outside of the cell.

To counteract the suppressed expression of 20K connexin fragments, Smyth used a lentivirus vector to cause the cells’ RNA to make 20k connexin, thereby rescuing the whole connexin 43, the formation of hole junctions, and cellular communications.

Teeth Enamel Created by Scientists Can Regenerate Easily

Jan 8, 2019

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Scientists at Queen Mary University of London have created another answer for develop mineralized substances which could regrow tough tissues like teeth enamel and bone.

Enamel, situated on the external piece of our tooth, is the hardest tissue in the body and makes the tooth function well in our lifetime in the midst of biting power, introduction to acidic foods and beverages and extraordinary temperatures.

This splendid performance comes about because of its organized structure.

However, enamel is not like the other tissues of the body because it cannot regrow once it’s lost, which can bring about pain and tooth loss.

These issues affect more than 50 percent of the population and so, discovering methods to regenerate enamel has been a primary need in dentistry.

Study of Tough Materials

The study, which was published in the journal Nature Communications, recommends this new technique that can make materials with correct accuracy and are like dental enamel.

The materials may be utilized for different dental issues, like tooth decay or teeth sensitivity, otherwise called dentin hypersensitivity.

The scientists noticed that the effortlessness and adaptability of the mineralization method opens chances to treat and recover dental tissues.

For instance, we could enhance acid-resistant bandages that may invade, mineralize, and shield dentinal tubes of human teeth for the treatment of dentin hypersensitivity.

The process that has been created depends on an assigned protein material that can set off and initiate the advancement of apatite nanocrystals at numerous scales, like how these crystals develop when dental enamel is created in our bodies.

This structural action is imperative for the awesome physical properties of dental enamel.

Other Uses

The researchers also noted that the principal purpose in materials science is to study from nature on how to increase valuable substances based on the unique work of molecular building blocks.

The important discovery has the possibility of taking advantage of disordered proteins to manage and mentor the system of mineralisation at more scales.

Through this, they have built up a framework to viably create artificial materials that copy such progressively organized architecture over substantial zones and with the capacity to tune their properties.

The control of the mineralization approach opens the likelihood to make substances with properties that copy particular tough tissues like enamel that are similar to bone and dentin.

Accordingly, the work creates learning to be utilized as a part of regenerative treatment.

Likewise, the investigation additionally introduces bits of knowledge into the functions of protein diseases in human physiology and pathology.

Nearsightedness Can Be Corrected by Noninvasive Technique

Jan 8, 2019

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Astigmatism, or nearsightedness, is a developing issue everywhere throughout the world.

There are presently twice the same number of people in the United States and Europe with this condition as there was previously.

In East Asia, 70 to 90 percent of adolescents and more young adults are myopic.

Through some estimates, about 2.5 billion of people around the world may be plagued by myopia by 2020.

Eye glasses and contact lenses are simple solutions; a more perpetual one is corneal refractive surgery.

But, even as corrective surgery has a high cost, it is an invasive approach, and can give rise to more surgical complications, and in rare instances, permanent vision loss.

Likewise, laser-assisted vision correction procedures similar to laser in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK) still utilize ablative science, which will disperse and lead to weakness of the cornea.

Noninvasive Technique of Myopia

Columbia Engineering specialist Sinisa Vukelic has built up another non-invasive procedure to accomplish the correct vision that demonstrates amazing promise.

His approach uses a femtosecond oscillator, a ultrafast laser that conveys pulses of low energy repeatedly for specific and localized adjustment of the biochemical properties of corneal tissue.

The method, which changes the tissue’s macro geometry, is non-surgical and has less symptoms and limitations than those observable in refractive medical procedures.

For example, sufferers with thin corneas, dry eyes, and diverse anomalies can’t have refractive surgery.

The examination, which would bring about treatment for nearsightedness, hyperopia, astigmatism, and sporadic astigmatism, was published recently in Nature Photonics �journal.

The researchers consider this study to be the first to use this laser output treatment for noninvasive alternative treatment of corneal curvature or treatment of other medical problems.

Femtosecond Oscillator

His approach uses a femtosecond oscillator to change biochemical and biomechanical properties of collagenous tissue without causing cell harm and tissue disturbance.

The procedure enables for adequate energy to result in a low-density plasma within the set focal quantity however, it does not deliver adequate energy to cause injury to the tissue within the treatment area.

The focal component to this approach is that the acceptance of low-density plasma realizes the ionization of water molecules inside the cornea.

This ionization creates a reactive oxygen species, a type of unstable molecule that includes oxygen and that readily reacts with other molecules in a cell, which in turn interacts with the collagen fibrils to create chemical bonds, or crosslinks.

The particular presentation of these crosslinks initiates changes in the mechanical properties of the treated corneal tissue.

At the point when this system is utilized in corneal tissue, the crosslinking adjusts the collagen properties in the areas, and this inevitably brings about changes in the aggregate macrostructure of the cornea.

The medicine ionizes the molecules inside the cornea while stopping optical breakdown of the corneal tissue. Given that the procedure is photochemical, it doesn’t upset tissue and the incited changes remain stable.

The specialists commented that what is amazing is that this strategy is simply not restricted to ocular media, but it might be utilized on various collagen-rich tissues.

They feel that this non-invasive strategy has the abilities to manage or reestablish collagenous tissue without creating tissue damage.

Vertigo: A New Type Identified Currently

Jan 7, 2019

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Neurologists have identified a new kind of vertigo with no known cause, according to a study released in the May 2018 issue of Neurology, the medical journal of the American Academy of Neurology.

With vertigo, individuals have dizziness that may last from minutes to days.

Vertigo can likewise be enhanced by medical conditions, similar to tumors, or conditions which can be mild, such as Meniere’s disease.

However, for some persons, no cause can be determined.

In this new investigation, neurologists have perceived another sort of vertigo where treatment is likewise �potent.

Recurrent Spontaneous Vertigo

According to the researchers, these stipulations may also be problematic to diagnose and fairly debilitating for men and women, so it is interesting to observe this new analysis of a condition that can respond to therapy.

To analyze this new condition, the individual sits in a dark room and the doctor strikes the patient’s head forward after which the ear is shaken on a level plane for around 15 seconds.

At that point the patient opens his or her eyes and a video recording is taken of eye movements.

The neurologists found out that after the test, subjects with this new condition had eye actions called nystagmus that lasted longer than other people.

The new condition is called recurrent spontaneous vertigo with head-shaking nystagmus.

Among 338 people with vertigo without a known reason, 35 had this condition and were involved in the investigation.

The members had attacks of vertigo for two or three times every week to about a year.

They additionally had nausea, vomiting, headache and head movements amid the attacks.

The subjects had been compared with 35 people with different conditions that may cause vertigo, for example, Meniere’s disease, vestibular headache and vestibular neuritis.

The test estimated the time interval, or the time that represents the speed with which the reflexive eye developments can react to change.

For this new condition, the time interval through nystagmus is 12 seconds, while it was six seconds for those with Meniere’s disease and 5 seconds for those with vestibular neuritis and vestibular headache.

Motion Sickness

The neurologists likewise found that people with this new kind of vertigo will probably have serious motion sickness than those with different sorts of vertigo.

Around 20 of the 35 individuals with this new kind of vertigo who had common attacks and serious indications got preventive treatment.

Around 1.33 of these had partial or complete recuperation with the new treatment.

In the lengthy-time period follow-up of 12 years after the first symptoms for 31 participants, 5 had no more attacks, 14 said that their symptoms had increased and only one stated that symptoms had gotten worse.

The specialists said that individuals with this condition can have a hyperactive component in their vestibular procedure that encourages the brain to react to body movement and the environment.

It appears to be likely that the vertigo happens when this unstable system is disturbed by reasons both inside the person’s body or in their environment.

Global Warming Limit Could Avert Many Cases of Dengue Fever

Jan 6, 2019

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Restricting global warming to 1.5 C would prevent around 3.3 million instances of Dengue Fever every year in Latin America and the Caribbean alone.

This is as per another investigation from the University of East Anglia (UEA).

Another report published within the Procedures of the National Academy of Sciences (PNAS) say that restricting warming as indicated by the UN Paris Agreement would likewise end dengue spread to regions where its rate is presently low.

Global Warming Limit and Dengue

An unnatural warming increase of 3.7C would prompt as much as 7.5 million further cases for each year in this century.

Dengue fever is an infectious disease which is caused by an infection that is spreading through mosquitoes, with signs including fever, fever, muscle pain, headache and joint pain.

It’s endemic to more than one hundred nations, and involves around 390 million individuals globally every year, with an expected 54 million cases in Latin America, the United States and the Caribbean.

Since the mosquitoes that transmit the infection flourish in warm and moist conditions, it’s seen in territories with these atmosphere conditions. There is no cure or vaccine for dengue and it is even deadly.

The specialists remarked that there might be a developing snag about the potential effects of environmental change on human health.

While it is perceived that constraining warming to 1.5C would have benefits for human wellbeing, the extent of the benefits stays obscure.

Decreasing Global Warming

As told by them, this is the essential investigation to show that decreased rates in warming from 2C to 1.5C could have numerous benefits.

The Paris Agreement expects to keep up world-average temperature �below 2C and to seek endeavors to confine it to 1.5 C above preindustrial levels.

The group examined medicinal and lab-confirmed dengue cases in Latin America and utilized models to predict the impacts of warming under exceptional atmosphere situations.

They have found that constraining global warming to 2C would prevent dengue cases by up to 2.8 million cases for each year toward the end of the century contrasted with the present, in which the worldwide temperature ascends by 3.7C.

Decreasing global warming further to 1.5C produces an extra drop in instances of up to half a million every year.

Southern Mexico, the Caribbean, northern Ecuador, Colombia, Venezuela and Brazil had the most increments in dengue cases.

Brazil would profit the most from constraining global warming to 1.5C with up to half a million cases prevented every year by the 2050s and 1.4 million prevented cases for every year by 2100.

The team additionally determined that limiting global warming would additionally restrict the increase in the disease cases closer to areas where incidence is currently low like Paraguay and northern Argentina.

Insomnia May Be a Long-term Side Effect of Stroke, Study Finds

Jan 6, 2019

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Stroke patients encounter supported issues with sleep deprivation presumably diminishing their capability to relearn key capacities and putting them at a higher risk for depression, another study in a journal finds.

In the primary investigation of its kind, analysts from the University of Surrey, University of Freiburg, Germany, and the University of Bern, Switzerland, did extensive sleep laboratory testing to look at the brain signs of subjects in the persistent state (no less than a year after stroke) and the present population.

Difficulties in sleep in people who had a stroke have long been reported, however little is known with regards to the brain indicators underlying bad sleep.

It is additionally unclear how individuals sleep inadequately in the night, subsequently prompting drowsiness and tiredness in the day.

Insomnia Study

Utilizing a polysomnogram test, which surveys the brains’ sleeping patterns for more than two nights, scientists have observed that it took stroke sufferers longer to sleep and that they had poorer sleep effectivity, which is the proportion of time invested in sleeping contrasted with the time spent in bed, than the individuals who did not have a stroke.

The sleep latency test also demonstrated that stroke patients will probably rest or sleep in the day to replace�during the evening.

They had been more prone �to mistakes in testing than their partners, developing their possibility of failures.

Significantly, scientists established that despite the fact that sleep effectivity is diminished in patients, total sleep between the groups are similar, recommending that diseases in the brain that affect sleep wake control will not cause insomnia.

On the other hand, specialists feel that sleep issues experienced by stroke patients are because of numerous reasons, for example, better psychological pressures, anger and discomfort and also diminished levels of physical activity.

Stroke and Insomnia

According to the researchers, people who have suffered stroke have difficulties with their sleep which is prone to affect their quality of life.

The estimation of sleep in supporting the recovery of sufferers must not be belittled in keeping up physical and �mental health.

They added further that sleep will not be considered for stroke rehabilitation, a limitation that will probably be revisited in time.

Bridling the intensity of good sleep will lead to good quality of life and personal satisfaction.

Global Pandemics May Be Due to Microorganism Characteristics

Jan 5, 2019

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Infectious disease preparedness concentrates predominantly on microorganisms that are used in biological warfare, political environments, and present outbreaks.

This neglects to represent the more serious microorganisms which are not generally known, as per students from the Johns Hopkins Center for Health Security, which were noted in their report of the characteristics of microorganisms with high pandemic capacities.

The Characteristics of Pandemic Pathogens

This report, “The Characteristics of Pandemic Pathogens,” launches a system for choosing common microorganisms that may create a global catastrophic biological risk (GCBR) and makes procedures for enhancing GCBR readiness.

GCBRs occur when biological agents would suddenly lead to a sudden, general catastrophe that is beyond the powers of governments and private companies to manage.

Not much data about GCBR agents exist, leaving the community to rely on past experiences to guide their preparedness goals.

According to the researchers, health security preparedness desires to be adaptable to new threats and should not be based entirely on historical reports.

A good strategy to this situation will, eventually, help defend against a GCBR event.

To define the discoveries and recommendations of their report, they looked into published writing and surveys on rising infectious disease qualities, the pathogenic nature of microorganisms, and other related points.

They talked with more than 120 specialists from the scholarly community, industry, and government and met a gathering with these authorities to examine about starting assessment of the expertise the staff had accumulated.

The first finding offered within this report outlines the usual traits of a GCBR-level pandemic pathogen.

Its method of transmission, the team has concluded, will be respiratory. It’ll be infectious amid the incubation period, preceding the development of symptoms, or when infected people give slight signs.

Eventually, it will want distinct host factors such as immunocompromise, and further intrinsic microbial pathogenicity traits that can enhance disease spread and illness.

The report additionally clarifies the pandemic capability of different microorganisms, noticing that RNA viruses are the biggest risk.

Strategies

The team recommends the following strategies:

Readiness against GCBR dangers ought to have a focus on approach with some adaptability.

Old pathogen strategies should not be permanent ideas that stultify considerations on pandemic pathogens.

Improving surveillance of human infections from respiratory-borne RNA viruses should be a greater priority.

A higher accentuation on setting up a particular pipeline of numerous antiviral agents for RNA respiratory infections – both broad spectrum and specific – would include versatility against known GCBR agents.�influenza vaccine

Vaccines towards RNA respiratory viruses, including a universal influenza vaccine, should be of priority.

A research agenda for upgrading the treatment of respiratory-spread RNA virus infections must be financed by pharmaceutical associations and medical device firms and sought after by medical centers.

Specific assessment is warranted for respiratory-borne RNA virus studies that could develop pandemic risks.

Pursuing special diagnoses of infectious diseases globally should be routine.

Childhood Insomnia Can Lead to Unhealthy Cholesterol Levels in Adulthood

Dec 30, 2018

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Researchers found that childhood insomnia have been associated with unhealthy lipid profile results, viewed as elevated levels of LDL.

Sleep has foremost benefits for health, wellbeing and cognitive efficiency.

In her doctoral dissertation, MA Liisa Kuula-Paavola from the University of Helsinki investigated ordinary, non-limited sleep and its effects over a growth span from middle childhood to early adulthood.

Longitudinal analyses revealed that childhood insomnia (a shorter sleep length and irregular sleep during childhood) have been associated with unhealthy lipid profile results, viewed as elevated levels of LDL or bad cholesterol and triglycerides and decreased levels of HDL or good cholesterol in early formative childhood years, especially among girls.

These associations were done while also taking into consideration body mass index and physical activity levels.

Sleep and Body Functioning

The dissertation’s reviews related to cognitive functioning additionally indicated that sleep length is also related to general body functioning, such as the capability to control one’s behavior.

Throughout early life, especially among boys, a shorter sleep period was associated with poorer performance in tests that evaluate body and mental health functioning.

The investigator noted that she observed identical results in young adults, but additionally discovered that later sleep timing and irregular sleep have been associated with weaker trait-like executive functioning, such as self-control and behavioral conduct.

She additionally analyzed the sleep patterns of distinct circadian type phenotypes longitudinally and observed that these adolescents who were always awake differed from the others with regards to sleep timing even at the age of 8.

This suggests long-term stability in sleep patterns.

Sleep and Health

Based on these findings, objectively measured sleep and its timing have longitudinal pathways which are related to future health and well being and may just act as risk factors or as starting reasons for various health-associated effects.

According to the investigator, it is likely that sleep, self-control, and health behaviors are intertwined throughout growth and development.

The study was conducted as a collaboration with researchers from the University of Helsinki’s Sleep and Brain study group and Developmental Psychology research team.

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