Brown University Researchers Have Created First Anti-Cancer Breast Implant
According to an article published in Nanotechnology, scientists at Brown University have created a breast implant which has the capacity to impede breast cancer cells regrowth. This implant is made from a polymer and it appears to have the capacity to impair blood vessel architecture in breast cancer tissue and in the same time to sustain healthy breast cells growth.
In terms of incidence after lung cancer, breast cancer is the second most common type of cancer, affecting one in eight women worldwide. The treatment of breast cancer, besides chemotherapy and radiotherapy, often requires a surgical intervention and breast reconstruction which is invols the use of breast implants. Due to the fact that cancer treatment is not always preventing malignant cell relapse, breast cancer recurrence rate in one-fifth of women originally diagnosed can be oberved.
Researchers have created a breast implant which can reduce the rate of relapse in breast cancer. This implant is made of a type of polymer which has on its surface nanometric nails (one-billionth of a meter, having 1/50, 000th of the width of of a human hair) that imper cancer cell growth. This type of breast implant is the first of its kind which can reduce cancer relapse and also made from a federally approved polymer that can cause a reduction in breast cancer cell blood-supply by interfering with tumor blood vessel architecture. It was also observed that this implants posses the capacity to promote healthy breast cell growth.
We've created an (implant) surface with features that can at least decrease (cancerous) cell functions without having to use chemotherapeutics, radiation, or other processes to kill cancer cells. It's a surface that's hospitable to healthy breast cells and less so for cancerous breast cells., researchers said.
In their study, scientists tried to modify the surface of various type of implants in order to promote regeneration of bone, skin, cartilage and other cells of the body. In this work, researchers tried to remodel a implant which can be used in surgical interventions for breast reconstruction, implant that possess the capacity to not only attract healthy cells, but also to interfere with breast malignant cell growth and proliferation. This implant was created by using 23-nanometer-diameter polystyrene beads and polylactic-co-glycolic acid (PLGA), a biodegradable polymer which is used widely in surgical stitches. After using this materials, researchers created an implant with a surface covered with 23-nanometer-high pimples. They also created implants that have on their surfaces 300-nanometer-high pimples and 400-nanometr-high pimples for comparison.
In laboratory tests it was observed that, implants that have on their surfaces 23-nanometer-high pimples posses the capacity to produce a reduction of 15 percent in the production of protein called VEGF, protein that is needed by endothelial breast malignant cells in their proliferation, compared with breast implants with no surface modification. Compared with 300-nanometer-pimple and 400-nanometer-pimple modified implants, the 23-nanometer-pimple implants showed the greater reduction in the production of VEGF proteins.
The reason why implants that have on their surfaces 23-nanometer-high pimples produce a greater reduction of VEGF proteins is unknown, but scientists believe that this event is linked to malignant cells stiffness, because when cancer cells come into contact with rough surfaces are unable to wrap around this surfaces and making them unable to ingest nutrients needed for growing and proliferation.
I would guess that surface peaks less than 23 nanometers would be even better.The more you can push up that cancerous cell, the more you keep it from interacting with the surface., researchers added
It was also observed that implants that have on their surfaces 23-nanometer-high pimples promoted the proliferation of healthy endothelial breast cell with 15 percent, compared with normal breast implants.