New Vaccine Prevents Weight Gain And Stimulates Weight Loss
In their effort to combat obesity, researchers have discovered a vaccine that prevents weight gain and stimulates weight loss. According to a study published in the Journal of Animal Science and Biotechnology, the researchers were able to induce weight loss following the administration of two vaccinations based on Â somatostatinÂ , JH17Â and JH18, in mice.
Somatostatin,Â hormone known as GHIH, is anÂ inhibitor of growth hormone. Growth hormone is an anabolicÂ peptide hormone that stimulates not only growth, cell reproduction and regeneration, but also increases metabolism and thereforeÂ promotes weight loss. Researchers have thought thatÂ by injectingÂ somatostatin,Â the body willÂ react andÂ produce antibodies against somatostatin, therefore theÂ inhibitory action of somatostatinÂ on growth hormone will be canceled. Consequently, growth hormone will increase theÂ metabolism without being inhibited by somatostatin. Besides stimulating lipolysis, growth hormone has a role in stimulating protein synthesis, muscle growth and bone mineralization.
Researchers conducted the study on two groups of mice: one groupÂ consisting ofÂ 10 mice with induced-obesity and the control group. TheÂ group of obese mice received two vaccinations of modified somatostatinÂ (first vaccine in the first day of the study andÂ the secondÂ – study day 22). The control group received saline injections. Obese mice were fed a high fat diet eight weeks before the study and six weeksÂ during theÂ study. After 4 daysÂ from the first vaccine,Â researchers found a decrease of 10%Â of body weightÂ among obese mice, observation that was not noted in the control group. At the end of the study scientistsÂ observed that the vaccines caused the appearance of anti-somatostatinÂ antibodiesÂ and a reduction in weight by 10%. It should be noted that researchers used a modifiedÂ form ofÂ somatostatinÂ that has not influenced the level or activity of insulin-like growth factor (IGF-1) or insulin.
Only time will tell if this vaccine will have similar results in humans. The idea ofÂ such a vaccine against obesity is not completely new. Not so long ago, researchersÂ created a vaccine based on ghrelin, a hormone with a role in appetite control. GhrelinÂ stimulates fat storage for energy. Researchers have thought that by suppressing ghrelin, fatty deposits will be destroyed. The idea was basedÂ on immune stimulation and anti-ghrelin antibody production.
Obesity is one of the most important problems of theÂ modern society. It is already known that obesity is associated withÂ various cardiovascular diseases, type 2 diabetes and certain types of cancer.Â Despite researchers attempts to discover a vaccine against obesity, at present the only successful therapy for weight lossÂ is based on diet, sports and some surgical interventions.