French Scientists Restored The Youth Of 100 Years Old Cells


    French researchers were able to restore the youth of cells taken from people aged over 100 years, reprograming them to stem cells stage, demonstrating that aging is in fact reversible. The research on the possibility to remove traces left by aging cells, published in the Genes & Development journal , marks a new stage in the regenerative medicine field, said Jean-Marc Lemaitre from Fonctionnelle Génomique Institute (INSERM / CNRS / Université de Montpellier), who led the study, informs AFP.

    The study contributed to another important achievement: a better understanding of aging and its pathological aspects correction, say scientists at INSERM.

    Old cells were reprogrammed to be pluripotent stem cells in vitro – IPSC (Induced pluripotent stem cells), which have the youth and characteristics of embryonic stem cells (hESC). They can differentiate back into cells of all types (neurons, heart cells, epithelial, liver etc) after the “rejuvenation” cure made by French scientists.

    Since 2007, scientists have shown that they can reprogram adult cells into pluripotent human stem cells (IPSC), whose properties are similar to those of embryonic stem cells. Those reprogrammed adult cells from avoid the criticisms regarding the use of embryonic stem cells.

    Before the great success of French researchers, reprogramming adult cells hit a limit, senescence, cellular aging ultimate point. The team of scientists led by Jean-Marc Lemaitre managed to exceed this limit.

    The researchers first multiplied epithelial cells (fibroblasts) from a donor aged 74 years to reach senescence, characterized by cessation of cell multiplication process. The researchers then conducted an in vitro reprogramming of these cells. Since this process was not possible through clasic preparation based on four genetic factors (OCT4, Sox2, Myc and KLF4 C), they added two more (NANOG and LIN28).

    With this new “cocktail” of six ingredients, reprogrammed senescent cells have regained the characteristics of pluripotent stem cells embryonic type without any trace of aging to preserve their past. Age markers were deleted from cells and the IPSC (Induced pluripotent stem cells)  that were obtained can produce all type of functional cells, with multiplication capacity and increased longevity.

    Researchers then tested the “cocktail” on older cells, aged 92 years, 94 years, 96 years and 101 years, the same success is achieved each time, including for the 101 year old cells.

    “Age is certainly not a barrier for cell reprogramming,” concluded the research leader.

    This study opens the way for using reprogrammed IPS cells as a source of adult cells ideally tolerated by the immune system to repair damaged organs or tissues in elderly patients.

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    1. […] in lab mice and rats, but getting it to work in human beings is going to be a new challenge. Via: Doctor TipsterTags: Aging, Cells, Doctors, Featured, Health, life, Research, Stem Cells, SurgeryCategory: Health, […]

      • There is restrictions. Not just any accident will do, unless a serious damage in the brain is induced, the least being brain death. Any shot in the body is worthless because immortal people have regenerative abilities, letting them heal constantly.

    2. In case I need to explain myself…epithelial cells are constantly shed and replaced over ones lifetime. Just because the donor is 100 years old doesn’t mean the individual cells the research was done on were that old.

      Mind you, the science and research behind the article is fine, it’s just a poor headline.

    3. I remember them talking about energy loop theory being able to make this happen. I didn’t think it would happen so soon though. Now what?

    4. […] de científicos en Francia han logrado restaurar las células de donantes de más de 100 años convirtiéndolas en células jóvenes. ¿Células inmortales? Quizá no tanto, pero los tratamientos “milagrosos” para rejuvenecer […]

    5. Quite interesting. Though as others have said it may be awhile before it’s ready to be used on humans… We’ll have to see where we are as a species, and if it will be available to all.

      If we all truly become immortal then we will have to discontinue having children. There are many factors that are being changed as a culture and species as we speak. I’m sure many more will have to be implemented if we become immortal.

    6. Might be a step to regeneration, immortality, the scatter of immoral deeds, and population supernova. I guess it’s better left the same as how it was several decades ago…

      • So…a few decades ago we didn’t have vaccines and antibiotics…I guess you’re right…it was better then..without todays medicine I would have died at least 6 times…how about you?

    7. […] “Old cells were reprogrammed to be pluripotent stem cells in vitro – IPSC (Induced pluripotent stem cells), which have the youth and characteristics of embryonic stem cells (hESC). They can differentiate back into cells of all types (neurons, heart cells, epithelial, liver etc) after the “rejuvenation” cure made by French scientists.” (Doctor Tipster). […]

    8. […] Adult stem cells found in the umbilical cord of newborns or in adults in various organs such as bone marrow, brain are called somatic stem cells. Initially it was thought that somatic stem cells can develop only into specicific types. In other words, if the cells came from bone marrow, it was thought that they can develop only into hematopoietic cells. But recently it has discovered that they can develop into another line. Furthermore, researchers were able to turn adult stem cells into embryonic cells by a method that is called reprogramming. […]

    9. We are all afraid of Death, because it is unknown and because the ones who have not yet died experience the death of others as a loss. But what if it’s actually a wonderful thing? A step up, or a next step along a grand adventure? We cling to the status quo, but there is no such thing. Everything is always in flux. We may be delaying or missing out altogether on that next great thing if we reach for “immortality”. Perhaps we are only reaching for a different kind of death. The death of further development. We may never know and we may be missing out…

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