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Hodgkin’s Malignant Lymphoma

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Hodgkin’s Malignant Lymphoma

Hodgkin malignant lymphoma is a malignant disease characterized by proliferation of malignant cells of the lympho-histiocytic system (immune system), plus a granulomatous inflammatory reaction (also malignant). Occurs more often in younger ages (18-25 and 40-50 beeing peaks of incidence) and represents approximately 30-40% of all malignant lymphomas.

Proliferating malignant cell is represented by Reed-Sternberg cell, whose origin may be in the lymphocytic series, or from the merger between B lymphocyte and a monocyte, under the action of Epstein-Barr virus or environmental factors (toxic chemicals) or other microbial agents. Present chromosomal abnormalities, not accidental (50% of cases) pleads for the neoplastic nature of Reed-Sternberg cell.