Morphine “ still a pain killer for everyone?
Pain is, as studies show, an element which diminishes life quality around the world. It is the foremost common symptom that affects individuals of any age, it varies in intensity and in onset. This symptom is not to be neglected or under-treated,however conjointly, it is not to be cured by over-medication. Studies show an upsetting high level of induced analgesic tollerance.
Morphine is the most used and preffered opium-based analgesic drug, in cases of severe unbareable pain. Morphine interacts with certain pain receptors spread throughout the brain, having the sole purpose of “numbing” the pain sensation.
However, studies have shown that the side effects of morphine does not include solely tollerance and addiction, but also a reversed effect from what it should normally have. This discovery has raised concerns among both researchers and people, who are faced with the puzzle of finding a treatment to the cause and the ways they can alter side effects of the most used analgesic on the market.
The researches conducted up to this point, have enabled specialists to differentiate between the response of morphine tollerance and worsening pain induced by it, thus allowing them to find a way around the problem, through a pathway which surpresses the side efect.
A molecule, reffered to as KCC2, has recentlybeen brought up as the main reason of pain hypersensitivity. This protein regulates management over sensory signals transmitted to the brain – therefor the logical explanation is that the repression of its activity,induced by the analgesics is, in fact, the reason behind pain hypersensitivity.
Further researches are to be conducted into the purpose of resolving the issue and restoring the quality of life in all patients.