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For people who suffer from various psychiatric and neurological conditions, brain stimulation has become an increasingly important treatment option in the recent decades.

Deep Brain Stimulation

Deep Brain Stimulation

Brain simulation techniques can be divided into two broad categories, invasive and noninvasive. Both of them work by targeting specific sites in the brain to adjust the overall brain activity. Among the most well-known invasive techniques is the deep brain stimulation (DBS) which requires a brain surgery and is approved by the U.S. Food and Drug Administration (FDA). This process is typically used for treated Parkinsons disease and this process requires an electrode to be inserted in the brain. Among the noninvasive techniques is the transcranial magnetic stimulation (TMS) which can be administered from outside the head. This treatment is currently approved for treating depression.

Brain stimulation has resulted in dramatic benefits to patients with such disorders, which has motivated researchers to test if it can be useful in treated patients suffering from other diseases. The problem is that doctors have been unable to pinpoint which are the ideal sites to administer simulation in a given patient for a given condition.

A new study led by investigators at Beth Israel Deaconess Medical Center (BIDMC) in the Proceedings of the National Academy of Sciences (PNAS) suggest that brain networks which consists of the interconnected pathways that link brain circuits to one another can assist in selection of ideal spot for brain stimulation therapies.

Michael D. Fox, MD, PhD, First author of the study, an investigator in the Berenson-Allen Center for Noninvasive Brain Stimulation and in the Parkinson’s Disease and Movement Disorders Center at BIDMC remarked that although different types of brain stimulation are currently applied in different locations, it has been found that the targets used to treat the same disease are nodes in the same connected brain network. This can have a direct implication on how brain stimulations are administered to treat diseases.

For example, in order use brain stimulation to treat Parkinson’s disease or tremor an electrode need to be inserted deep in the brain. Getting the same effect with noninvasive stimulation is difficult, as the spot is deep in the brain. However, by looking at the brain’s network connectivity, sites can be identified on the surface of the brain that is connected with the deep spot site. Hence, that deep spot can also be stimulated noninvasively.

For this study Foxs team conducted a large-scale literature search to find out all neurological and psychiatric diseases where brain stimulation via both invasive and non-invasive techniques had shown improvement. The search found 14 such conditions namely addiction, Alzheimer’s disease, anorexia, depression, dystonia, epilepsy, essential tremor, gait dysfunction, Huntington’s disease, minimally conscious state, obsessive compulsive disorder, pain, Parkinson disease and Tourette syndrome. In the next step, they listed the stimulation sites, both deep in the brain or on the surface of the brain that was found to have been effective for the treatment of each of the 14 diseases.

In order to test the hypothesis that the various stimulation sites in the brain are different spots within the same brain network, Foxs team used a data base of functional MRI images and a technique that enabled them to see correlations in spontaneous brain activity. These correlations helped the investigators in creating a map of connections from deep brain stimulation sites to the surface of the brain. When this map was compared to sites for noninvasive brain stimulation on the brain surface, the two matched.

The study suggest that understanding the brain networks can help in understanding why brain stimulation works and how these therapies can be improved by identifying the best place to stimulate the brain for a given patient suffering from a given disease. These findings also suggest that resting-state functional connectivity can be useful for translating therapy between treatment modalities, optimizing treatment and identifying new stimulation targets.




cbd oil

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A???rd?ng t? M?d???l News T?d??, th? body’s ?nd???nn?b?n??d ???t?m h?? tw? ??nn?b?n??d receptors: CB1 ?nd CB2.

M??t CB1 r????t?r? ?r? found ?n th? br??n ?nd ?r? associated w?th ??gn?t?v? ??t??n? r?l?t?d t? coordination, m??d, thinking m?m?r?, ?nd ????t?t?. CB2 receptors, ?n th? ?th?r h?nd, ?r? found ?n th? immune ???t?m. Th?? m?k?? th?m m?r? responsible f?r th? body’s r????n?? t? ???n ?nd ?nfl?mm?t??n.

Tetrahydrocannabinol, ?r THC, ?tt??h?? t? CB1 receptors, wh??h ?x?l??n? wh? ?m?k?ng ?r ?ng??t?ng m?r?ju?n? ?ff??t? u??r? ??gn?t?v?l?.

H?w?v?r, CBD ?ff??t? CB2 r????t?r?. And ?t d??? ?? ?nd?r??tl?, n?t b? b?nd?ng t? th? CB2 r????t?r, but b? ?ttr??t?ng th? b?d? t? produce m?r? th?n ?t? ??nn?b?n??d?. Th?? ?r??t?? a ????t?v? ?ff??t ?n b?d? ???n ?nd r????n??? t? ?nfl?mm?t??n.

Advantages ?f CBD oil

M?n? studies h?v? b??n ??ndu?t?d ?n CBD ?nd h?v? found th?t th?? ??m??und offers num?r?u? ??t?nt??l benefits t? ?nd?v?du?l? d??gn???d w?th arthritis.

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A ?tud? published ?n th? j?urn?l P??n ?n December 2017 analyzed wh?th?r CBD ??uld ?r?v?nt osteoarthritis ???n ?nd joint neuropathy. Based on th??r f?nd?ng?, th? r????r?h?r? stated th?t h? d?d b?th b???u?? ?t r?du??d joint ?nfl?mm?t??n ?nd served ?? a ?r?t??t?r ?f nerves.

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Oth?r ?tud??? h?v? r???rt?d positive effects f?r ????l? t?k?ng CBD t? relieve th??r ???n fr?m f?br?m??lg??, m?n? ?f wh??h h?v? ?nl? h?d m?ld ??d? ?ff??t? fr?m th?? chemical compound, ?u?h ?? dr? mouth, sleepiness, ?nd d?zz?n???.

CBD ??l ?nd ?nx??t?

CBD ??l h?? ?l?? b??n l?nk?d t? a v?r??t? ?f m?nt?l h??lth b?n?f?t?, ?u?h ?? r?du??d ?nx??t?. Research suggests th?t ?t ?? ?? effective ?n th?? r?g?rd th?t ?t h?? “??n??d?r?bl? potential ?? a tr??tm?nt f?r mult??l? ?nx??t? disorders.” A ?tud? published ?n Th? P?rm?n?nt? J?urn?l h?? ?v?n f?und th?t CBD oil ??n help r?du?? ?nx??t? ?n ??ung ?h?ldr?n.

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S?v?r?l studies h?v? ?l?? l?nk?d CBD t? a reduction ?n ??m?t?m? associated w?th d??r?????n. Th?? ?? ?xtr?m?l? ?m??rt?nt b???u??, ?? ?t?t?d b? th? Arthritis Foundation, th? d??r?????n rates ?f th??? d??gn???d w?th a ??rt??n type ?f ?rthr?t?? “??n b? b?tw??n tw? ?nd t?n t?m?? h?gh?r th?n th? rates ?f th? g?n?r?l ???ul?t??n.”

I? CBD ??l legal?

Alth?ugh CBD ??l h?? a numb?r ?f potential benefits, ?n? ?f th? m??n questions th?t individuals d??gn???d w?th rh?um?t??d ?rthr?t?? h?v? ?? wh?th?r ?t ?? legal ?r n?t. An?w?r?ng th?? question r??u?r?? ??m? und?r?t?nd?ng ?f components ?f th? m?r?ju?n? plant.

Th? m??t w?ll-kn?wn compound ?n th? ??nn?b?? plant ?? THC. Th?? ?? th? chemical responsible f?r th? ?nf?m?u? m?r?ju?n? t??. H?w?v?r, unlike THC, CBD Oil Tincture h?? n? ????h???t?v? ?r???rt???. Th?? means th?t ?t d??? n?t ?r??t? th? ??m? ?ff??t th?t ?? normally ?bt??n?d wh?n smoking, ?nh?l?ng, ?r ingesting m?r?ju?n?. Furth?rm?r?, th? US Drug Enf?r??m?nt Adm?n??tr?t??n (DEA) ?t?t?? th?t THC m?k?? m?r?ju?n? illegal ?n ??v?r?l ?t?t??.

dental check-up

Just like the rest of ones body, your oral health is very important. Neglecting it can result in a lot of consequences in the future such as tooth decay, tartar, and even heart disease caused by gum disease. It is then necessary that you should regularly visit your dentist for a proper consultation and checkup. It is highly recommended to visit your dentist at least every 6 months. But there will be times where we simply dont have the luxury of time and resources to visit regularly so make sure to schedule it even at least once a year.

Heres why it is important to go to the dentist annually.

1.         You get a proper checkup and dental services.

While there are several things we can do on our own, an annual visit to your dentist will allow you to get a proper checkup and other dental services. Your dentist will be able to assess if your oral health is healthy. They will also be able to check if you need to take extra precautions and whatnots. This is why finding a good dentist in your area is important so you can easily visit them. Try to search on Google by putting dentist 89148. That way, you will find the best dentists in your area.

2.         You will have a proper dental cleaning.

Oral prophylaxis or simply put, a dental cleaning should be done at least once a year to remove plaque and tartar on your teeth. Otherwise, it will harden and may lead to oral diseases. This is something you should be careful of. Your dentist will clean your teeth professionally and provide you the best product recommendations to use for your teeth and gums.

3.         Your gums will be thoroughly checked.

An annual checkup will also help you get an assessment on gum disease and others. There will be a careful examination of your throat, tongue, face, neck, and gums. Your dentist will be able to check and determine any signs of trouble or swelling and even possible signs of cancer. These are things that only dental professionals will be able to properly assess. So visiting your dentist at least once a year is very important to stay healthy and well-informed.

4.         Bad oral habits can be detected and corrected.

You may have some habits that you had no idea can destroy your oral health. Getting an annual consultation and cleaning with your dentist will allow you to have your oral habits checked and corrected. This may include grinding your teeth, clenching your jaw, smoking and drinking too much coffee. Your dentist will be able to provide you some tips on how you can avoid this.

5.         Determine any problems that are beyond the eye.

Some problems lie underneath and are not visible to the naked eye. Visiting a dentist will help you get a dental x-ray to see if there any underlying problems to be wary of. Some examples of this are impacted wisdom tooth or additional growing teeth.

drug addiction

Are you worried your kid is using drugs?

We dont mean to scare you off, but there are high chances he is. But, you can confirm your doubts if you pay attention to the following!

Physical Changes

Physical Changes are a major indicator that your child is using some sort of drugs. Drug addiction and alcoholism lead to several physical changes, especially when the user struggles with the dependency of the drug. It develops an unhealthy look on the users face and body. Their personal hygiene also goes into turmoil. Some of the major physical signs that show your kid is taking drugs are given below:

  • Eyes become red, and the pupil gets small
  • Constant Nose-bleeding
  • Changes in sleep pattern and appetite
  • Lack of Personal grooming and deteriorating physical appearance
  • Impaired coordination and injuries or bruises
  • Bad breath and body odor
  • Shapes, incoherent speech, impaired coordination, and tremors

These are some common signs of drug uses. These signs do change or alter based on the type of drug your child uses. For instance, if your child abuses proved peptides, fainting and excessive sweating are evident signs. The signs also signify dependency. In worse stages, the user has stains on faces with traces of chemical breath. Stimulant addiction is also associated with nose-bleeding, running nose, etc.

Emotional Change

Addiction to drugs can change brain chemistry, which alters a persons mood and behavior. Continuous use of drugs can lead to the following emotional changes:

  • Extreme Mood Swings
  • Lethargy
  • Hyperactivity or Agitation
  • No General Interest
  • Anxiety
  • Withdrawal symptoms

These are far worse than physical effects. Major reason parents dont notice these signs is because they are not very apparent. In most cases, parents are unable to recognize these symptoms and cant tell the difference in personality changes of their kid.

In case you notice any of these symptoms, there are high chances your child is using drugs. Depression and aggression are also signs of drug addiction. This will lead to an emotional fallout sooner or later. This will be followed by some emotional backlash.

Social Change

Based on the above two symptoms, there are high chances that your childs social behavior will also change. Yes, if you are observant, you will see they are undergoing a social change. Addicts are secretive about their drug use or abuse, but the addiction becomes difficult to hide at a given point. If your kid is abusing drugs, you will see their behavior will change along with their physical and emotional outlook.

Following, we are mentioning some of these changes:

  • They skip class, their grades get bad, or they often land in trouble at school
  • They are not interested in social activities; they dont have any hobbies
  • They dont go out
  • There are complaints of unusual behavior from friends, co-workers and even classmates
  • Their relationship, friendship and hobbies change
  • They become isolated
  • They request and start burrowing money

If you notice these signs, then act right away, dont sit on it, it will make things much worse.

relationship to the next level

Recent studies have revealed that not only has the use of sex toys for men, women & couples increased over the past decade, the taboos surrounding their use have also declined. Enhancing pleasure should be the goal of any sexual encounter, but there are times when both men and women feel pressured by such expectations. This is where items like bondage pleasure toys and other sex toys, available easily on online sex stores can be of huge help.

In fact, research indicates that regardless of demographic or sexual orientation, the use of such toys enhances pleasure and leads to better bonding in a relationship. It is important to overcome the misconception that using sex toys means that you arent good enough in bed, says Nova Desire, a leading online sex store.

Heres a look at the advantages you stand to gain when you use the services of an online sex toy store.

1.    Enhances Communication

The communication starts right from checking out the products online and making a choice that both partners agree on. It is a proven fact that when partners discuss their sexual needs and preferences with each other, they feel more bonded. This is only the beginning of open communication between you two.

2.    Relieves the Pressure to Perform

Did you know that one of the common causes of erectile dysfunction is the pressure to perform in bed? High anxiety can lead to reduced libido too, and not just for men. If you were to introduce a toy for women & couples, both partners could experience a stress-free and more enjoyable time together. Plus, it definitely adds spice to the relationship.

3.    Increases Intimacy

Helping each other climax with the use of sex toys for men, women & couples can help you overcome inhibitions and feel closer to your partner. For instance, using bondage pleasure toys can help you explore new sexual interest with each other, which will enhance intimacy. And, increased intimacy in bed translates to a better relationship outside the bedroom too.

4.    Leads to Better Sex

Well, thats what theyre created for, after all. Whether you use them solo or with your partner, it can definitely lead to more pleasure and maybe even more orgasms! They also help with foreplay, ensuring better arousal and therefore higher levels of bigger climaxes. Studies have proven that when you have a satisfying sex life, your relationship is stronger too. In fact, a study published in the Journal of Sex Research in 2016 reveals that couples who use such toys reported better sexual communication, sexual acts and mood, leading to greater satisfaction and a better overall relationship.

The best part is that with the availability of sex toys on online stores, it has become very easy and not embarrassing at all to browse through various toys, compare and discuss and finally buy them. And, they are delivered right to your doorstep. So, what are you waiting for? Take your relationship to the next level by spicing up your sex life today.

Maybe you have been consuming a lot of junk food, alcohol, and drugs in your life and you have decided that you want to turn your life around. You have decided to complete a full body detox but you do not know how to do this or where to start. Detoxification involves the cleansing of the internal organs of the body from food waste, poisons, harmful bacteria, environmental pollutants, and other substances. This is much easier than you can imagine, it just takes a few small steps to make your body healthy again and change your lifestyle.

full body detox

1. Limiting Alcohol

Limiting alcohol is important to prevent damage to your liver function, and to keep your body’s detox system running strong. About 90% of alcohol is metabolized into your liver and liver enzymes metabolize alcohol to acetaldehyde which is a chemical that causes cancer. Excessive drinking causes inflammation, scarring and fat buildup in your body. This prevents your liver from functioning properly and performing its necessary tasks. Your liver is responsible for filtering out toxins and waste from your body and it can not do this properly with excessive drinking. If you struggle with alcohol addiction, you must seek help from centres such as inpatient rehabilitation, to live life addiction-free and healthy.

2. Drinking More Water

Drinking enough water does much more than quench your thirst. It helps with digestion, nutrient absorption, lubricates joints, regulates body temperature and detoxifies your body. To function properly, and break down nutrients in your body and then convert it into energy, your body cells must constantly be prepared. Water helps remove harmful wastes from your body through sweating, breathing, and urination. It is important to stay hydrated to receive detox benefits. Your daily water intake depends on where you live, your diet, and your activity level. Women should consume 2.7 litres of water a day while men should consume 3.7 litres.

3. Getting Enough Sleep

Getting enough sleep also helps support your body’s detox system and overall health. Sleeping allows your brain to recharge and remove toxins waste byproducts that have accumulated throughout the day. One of these waste products includes beta-amyloid which aids in the development of Alzheimer’s. If you do not get enough sleep, toxins can build up in your body and your body cannot perform natural functions. Lack of sleep causes heart disease, obesity, high blood pressure, anxiety, and stress. It is important to get 7-9 hours of sleep every night.

4. Reduce Intake of Processed Foods

High processed foods are linked to obesity and diseases such as diabetes, cancer, and heart disease. These diseases make the body unable to detoxify itself because it harms your organs such as your kidney and liver. Even sugary beverages like soda can cause you to have a fatty liver which decreases your liver’s ability to function. By eating healthier foods, you can keep your body’s detox system healthy.

Adding fruits and vegetables to your diet can help guide you to eating healthier. Foods that are rich in antioxidants protect your cells against damage. Damaging body cells can cause heart disease, asthma, and cancer. Antioxidants help your body fight stress and other toxins. Antioxidants with Vitamin C, E, AND A are commonly found in fruits, nuts, spices, vegetables, and green tea. Prebiotics is a fibre that puts good bacteria into your body and it helps keep your immune system and detox system healthy.

5. Decreasing Salt Intake

Decreasing salt intake is very beneficial to your body’s natural detox system. If you consume too much salt, your body will retain excess fluid. This can cause bloating but if you drink more water you can eliminate this excess water weight. When you consume a lot of salt but don’t drink enough water to cleanse your system, you will be unable to urinate. Urination is what helps eliminate excess water and waste products. You can also increase your intake of foods with potassium to balance sodium’s effects on the body.

6. Exercising

Exercising helps you to increase your life span and reduces many diseases and conditions including heart disease, cancer, high blood pressure, and diabetes. Too much inflammation can cause your body to be weak but if you exercise you can reduce inflammation and allow your body’s detox system to protect you against diseases and allow your body to function properly. Walking or running is recommended during the week to keep your body in shape.

Exercise also helps the body detox by reducing fatty tissue and eliminates them through the cleansing organs. Moving the body helps circulate blood and the more blood circulates, the more the liver can work towards purifying and cleansing lymph and blood. We eliminate a lot of toxins when we sweat so when we workout we are cleansing our body’s out when we perspire.

metabolic disorders

As an expectant parent, you likely spend your days eagerly anticipating the birth of your baby. Will it be a girl or a boy? What will he or she look like? Will she have her moms curly hair? Will he have his dads deep blue eyes?

But in the back of your mind, you likely also worry. Will (s)he be healthy and happy from the beginning of his or her life or will (s)he initially be colicky, cranky, and cry a lot?

Genetic Metabolic Disorders

Unfortunately, if both you and your spouse unknowingly carry a gene for a recessive metabolic disorder, your baby likely will be born with one since (s)he will have two such genes. According to the Health Resource and Services Administration, over 5,000 babies in the U.S. are born with metabolic disorders.

A metabolic disorder is a condition that makes it difficult for your child to get nutrients from the food (s)he eats because his or her body cannot break down carbohydrates, proteins, and/or fat. Consequently, (s)he cannot produce the energy (s)he needs.

birth injury attorney in Columbus, OH, explains that untreated infant metabolic disorder can lead to serious health complications. Early symptoms can include the following:

  • Poor appetite
  • Abdominal pain
  • Failure to thrive
  • Weight loss

If the metabolic disorder goes undiagnosed and untreated, however, more serious consequences can include seizures, coma, and eventually death.

PKU Test

You will be glad to know that all babies born in the U.S. must, by law, undergo a test, called the PKU test, that screens for metabolic disorders. Within 48 hours of your babys birth and prior to his or her release from the hospital, a health care professional will draw a little blood from one of your baby’s heels and send it to a screening lab. This test screens for over 30 metabolic diseases. If the test comes back positive, you and/or your babys pediatrician will receive a notification.

Some conditions the PKU test screens include the following:

  • Galactosemia: inability of your baby to process sugar that can lead to liver disease
  • Lysosomal storage disorders: conditions that let toxic substances build up in your babys body and lead to liver injury, heart damage, nerve damage, or stroke
  • Maple-syrup urine disease (MSUD): an enzyme deficiency that allows amino acids to build up in your babys body that causes his or her urine to smell like maple syrup and can lead to nerve damage
  • Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: inability of your baby to convert fat into energy
  • Metal metabolism disorders: conditions such as Hemochromatosis (excessive iron in your babys body leading to liver damage) and Wilsons disease (excessive copper in your babys body leading to liver and/or brain damage)
  • Phenylketonuria (PKU): an enzyme deficiency that can lead to decreased brain function and/or mental retardation

Metabolic Disorder Treatments

Since a metabolic disorder causes your baby to have too much or too little of certain substances and nutrients, treatment generally consists of feeding him or her a special diet. For instance, if (s)he suffers from PKU, youll want to feed her a phenylalanine-free formula and later a diet low in high-protein foods. If (s)he suffers from galactosemia, you will need to feed him or her a non-dairy formula free of lactose. Your pediatrician will recommend the special diet your baby needs.

While a metabolic disorder diagnosis can be a scary and confusing thing since there are so many such disorders, know that your child can live a full and healthy life if you begin carefully managing his or her formula immediately after birth and later the foods (s)he eats. You will need to get into the habit of carefully reading the labels on food products so you can prevent him or her ingesting foods that could harm him or her. You will also need to educate him or her from early childhood as to the foods (s)he can and cannot eat.