Breast fibroadenoma is a benign tumor characterized by proliferation of stromal and glandular elements of the breast. It is the most common form of benign breast tumor and is observed in the first three decades of life. Formation appears as single, rarely multiple 1-5 cm diameter, well delimited, withÂ a smooth surface, mobile on the over and underlying plans, rarelyÂ adjacent to the skin, painless,Â do not change during the menstrual cycle andÂ regress atÂ menopause.
The etiologyÂ incriminatedÂ is changes in plasma estrogen levels andÂ changes in theÂ estrogen%progesterone ratios.
Causes Of Breast Fibroadenoma
FibroadenomasÂ are benign tumors composed of stromal and epithelial cells. They are seen mostly in young women. Multiple fibroadenomas may indicate a slightly increased risk of breast cancer. Patients with fibroadenoma,Â have a increased risk ofÂ approximately two times compared to healthy ones. These tumors shows hyperplastic or proliferating processes in a single ductal unit. Their development is considered an aberration of normal development of the breast. The cause of these tumors is unknown. Approximately 10% of fibroadenomas spontaneously disappear every year, andÂ in most ceasesÂ they stop growing after reaching 2-3 cm.
Fibroadenoamas canÂ regress in postmenopausal women. They can develop intraductal calcifications. Conversely, can grow rapidly in pregnancy, hormonal therapy or immunosuppression, in which case malignant trasnformation is stimulated. Immunosuppression in patients with multiple fibroadenoamas relates to Epstein-Barr virus infection.
BreastÂ Fibroadenoma Signs And Symptoms
Fibroadenoma may occur in girls and women of any age. Tumors generallyÂ regress after menopause. They rarely occur inÂ elder women, so any new solid lesion in an elderly woman should be considered malignant until proven otherwise. Cancers are the most common solid tumors in postmenopausal women.
Fibroadenoma has aÂ prevalenceÂ of 7-10 percentÂ in women over 40 years. FibroadenomaÂ is the most common solid breast tumors after breast cancer.Â Fibdroadenoamas are common in young womenÂ due to theÂ fact thatÂ woman underÂ 40 are not investigatedÂ using imaging methods. Detection throughÂ palpation is the most common method by which tumors are discoveredÂ in this age group.
OnÂ clinical examination fibroadenoma lesions are round, movable, elastic, can be palpable or nonpalpable. Their size varies from 1 cm to 15 cm in diameter.
Most often, the tumors are removed when they have between 2-4 cm in diameter. Young women usuallyÂ present palpable tumors. Fibroadenoma isÂ often detected accidentally at a medical examination or self-examination as a discrete solitary mass of 1-2 cm. Although they may be located anywhere in the breast, they are frequently discovered in the upper quadrant. Fibroadenomas have a consistency of rubber they are soft andÂ painless.
Cancer canÂ be caused by the presence of a fibroadenoma.Â IncrisingÂ size, changes in marginÂ regularity and small calcification development suggestÂ theÂ onset ofÂ breast cancer.