New Compounds Effective Against Antibiotic Resistant Infections Discovered
A new class of compounds that can tackle antibiotic resistant infections with a reduced chance of developing resistance was discovered by reseachers at the University of Michigan. The results were published online in the Proceedings of the National Academy of Sciences.
After screening and testing several compounds, researchers from the Center Of Chemical Genomics discovered a new class of drugs that can inhibit the growth and spread of Group A Strep in mouse models. Their findings suggest that these small molecules could have similar effects in treating infections caused by group A Streptoccoccus in humans.
Some pathogens have acquired resistance to drugs due to too long or too short antibiotic treatment periods. Frequent administration of antibiotics has encouraged the emergence of resistant bacterial species and therefore of harder to treat infections. Antibiotic resistance is one of the major public health problems. The National Academy of Sciences estimated that such resistant infections cost U.S. society at least $4 to $5 billion each year.
Antibiotics in use today act by interfering with the bacterial metabolism to kill or stop its growth. Meanwhile better adapted strains can elude the antibiotic attack and continue to multiply.
When germs become resistant to certain antibiotics, the treatment scheme must be changed with other antibiotics combinations. This is only a temporary solution for. It is therefore very important that antibiotics to be prescribed and used rationally.
An alternate approach is to deprive bacteria from nitric oxide, making them vulnerable and therefore easier to kill. Thus, the required dose of antibiotics is lowered and less toxic to the body (following the exposure to antibacterial substances and antibiotics, bacteria produce nitric oxide, which makes them much stronger and more resistant to aggressive factors. One such aggressive factor are antibiotics, exercising an oxidative stress on the pathogens similar to the effect free radicals have on human tissues like tobacco smoke, pollution, food additives and so on.)
Combining conventional treatment options for Group A Streptococcal infections like penicillin with these newly discovered compounds can result in more effective ways to avoid the selection of antibiotic resistant strains and achieve better treatment results.