A highly elastic and adhesive surgical glue that quickly seals wounds without the need for common staples or sutures could transform how surgeries are performed.
Biomedical engineers from the University of Sydney and the United States collaborated on the development of the potentially life-saving, called MeTro.
MeTro’s high elasticity makes it ideal for sealing wounds in body tissues that continually expand and relax such as lungs, hearts and arteries, which are otherwise at risk of re-opening.
The material also works on internal wounds that are often hard-to-reach areas and have typically required staples or sutures due to surrounding body fluid hampering the effectiveness of other sealants.
MeTro sets in just 60 seconds once treated with UV light, and the technology has a built-in degrading enzyme which can be modified to determine how long the sealant lasts from hours to months, to allow adequate time for the wound to heal.
The liquid or gel-like material has quickly and successfully sealed incisions in the arteries and lungs of rodents and the lungs of pigs, without the need for sutures and staples.
The results were published in Science Translational Medicine, in a paper by the University of Sydney’s Charles Perkins Centre and Faculty of Science; Boston’s Northeastern University, the Wyss Institute for Biologically Inspired Engineering at Harvard University and the Beth Israel Deaconess Medical Center (BIDMC) in Boston.
MeTro combines the natural elastic protein technologies developed in collaboration with author and University of Sydney McCaughey Chair in Biochemistry Professor Anthony Weiss, with light sensitive molecules developed in collaboration with author and Director of the Biomaterials Innovation Research Center at Harvard Medical School Professor Ali Khademhosseini.
Lead author of the study, Assistant Professor Nasim Annabi from the Department of Chemical Engineering at Northeastern University, oversaw the application of MeTro in a variety of clinical settings and conditions.
“The beauty of the MeTro formulation is that, as soon as it comes in contact with tissue surfaces, it solidifies into a gel-like phase without running away,” she said.
“We then further stabilise it by curing it on-site with a short light-mediated crosslinking treatment. This allows the sealant to be accurately placed and to tightly bond and interlock with structures on the tissue surface.”
The University of Sydney’s Professor Anthony Weiss described the process as resembling that of silicone sealants used around bathroom and kitchen tiles.