Researchers on The Ohio State University Wexner Medical Center and Ohio State’s College of Engineering have developed a new device, the Tissue Nanotransfection (TNT), that may generate any cell type for treatment in the body. This science may be used to restore injured tissue or fix function of aging tissue, including organs, blood vessels and nerve cells.
The outcome of this regenerative medication study is released in the journal Nature Nanotechnology.
According to Dr. Chandan Sen, director of Ohio State’s Center for Regenerative Medicine & Cell Based Therapies, who co-led the study with L. James Lee, professor of chemical and biomolecular engineering with Ohio State’s College of Engineering in collaboration with Ohio State’s Nanoscale Science and Engineering Center, By using our novel nanochip technology, injured or compromised organs can be replaced. We have shown that skin is a fertile land where we can grow the elements of any organ that is declining
Researchers studied mice and pigs in these experiments. In this particular study, researchers have been equipped to reprogram skin cells to be vascular cells in badly injured legs that lacked blood flow. Within one week, active blood vessels appeared in the injured leg, and by the second week, the leg was treated. In lab tests, this science was also found to reprogram skin cells in the body into nerve cells that have been injected into brain-injured mice to aid them in recuperating from stroke.
According to Sen, This is difficult to imagine, but it is achievable, successfully working about 98 percent of the time. With this technology, we can convert skin cells into elements of any organ with just one touch. This process only takes less than a second and is non-invasive, and then you’re off. The chip does not stay with you, and the reprogramming of the cell starts. Our technology keeps the cells in the body under immune surveillance, so immune suppression is not necessary.
TNT technology has two major components: first is a nanotechnology-based chip designed to deliver to adult cells in the live body. The second is the design of biological cargo for cell conversion. This cargo, when delivered utilising the chip, converts an adult cell from one form to another. This is according to Daniel Gallego-Perez, an assistant professor of biomedical engineering and general surgery who also was a postdoctoral researcher in both Sen’s and Lee’s laboratories.
TNT does not require any laboratory-founded approaches and could also be implemented at the point of care. The system can be non-invasive. The cargo is delivered by zapping the gadget with a small electrical charge that is barely felt.