A study from the City of Hope discovered that using low-dose aspirin (81mg) reduces the chance of having breast cancer in females who have been a part of the California’s Teacher’s Study. This study, which is the first to recommend that the decrease in risk occurs for low-dose aspirin, was proposed by City of Hope’s Leslie Bernstein, Ph.D., professor and director of the Division of Biomarkers of Early Detection and Prevention, and published online in the journal, Breast Cancer Research.
Bernstein and her colleagues noticed an overall 16 percentage decreased risk of breast cancer in females who used low-dose aspirin at a minimum of thrice per week. Such regular use of low-dose aspirin diminished the chance by 20 percent of estrogen or progesterone receptor positive, HER2 negative breast cancer, which is the most common breast cancer subtype.
Association Between Aspirin And Female Breast Cancer
According to the lead author Christina A. Clarke, Ph.D., M.P.H., from the Cancer Prevention Institute of California, The study found an interesting protective association between low-dose aspirin and breast cancer. We did not by and large find associations with the other pain medications like ibuprofen and acetaminophen. We also did not find associations with regular aspirin since this type of medication is taken sporadically for headaches or other pain, and not daily for prevention of cardiovascular disease.
This one differed from other studies which have checked out aspirin and cancer risk considering that it focuses on the dose levels of the aspirin that the females had taken and tracked the frequency of use of low-dose aspirin versus regular aspirin. It was also equipped to appear in detail at subtypes of breast cancer.
According to Bernstein, We already knew that aspirin is a weak aromatase inhibitor and we treat women with breast cancer with stronger aromatase inhibitors since they reduce the amount of estrogen postmenopausal women have circulating in their blood. We thought that if aspirin can inhibit aromatase, it ought to reduce the likelihood that breast cancer would develop and it could also be an effective way to improve breast cancer patients’ prognosis once they no longer take the more potent aromatase inhibitors. Aspirin also reduces inflammation, which may be another mechanism by which aspirin taken regularly can lower risk of breast cancer developing or recurring.
The researchers analyzed information recorded in questionnaires submitted by 57,164 females within the California’s Teacher’s Study. In 2005, members answered questions related to past history of cancer and other conditions, use of aspirin and different nonsteroidal anti-inflammatory medicines (NSAIDS), menstrual and reproductive history, use of hormones, weight and height, dwelling atmosphere, diet, alcohol use and physical activity. Within the ensuing years earlier than 2013, 1,457 of these participants developed invasive breast cancer.
The group of researchers selected to focus on low-dose aspirin, for the reason that not only is it low cost and without problems but it may also be used as prevention, since there are already plenty of people already taking it for prevention of other illnesses such as heart disease and even colon cancer.