A new study suggests that tomato extract from two Southern Italy cultivars inhibit gastric cancer cell growth and malignant development, paving the way for future reviews geared toward enforcing healthy habits not just for prevention, but also as a help for conventional treatments. According to Daniela Barone, researcher at the Oncology Research Center of Mercogliano (CROM), and one of the authors of the study, “Their antitumoral effect seem not related to specific components, such as lycopene, but rather suggest that tomatoes should be considered in their entirety.”
Effects Of Tomato Extract On Gastric Cancer Cells
The studies analyzed whole tomato lipophilic extracts for their potential to deal with various neoplastic points of gastric cancer cells. Extracts of both the San Marzano and Corbarino tomato varieties had been capable of inhibiting the development and cloning behavior of malignant cells. Treatment with the whole tomato extracts affected key processes within the cells hindering their migration potential, arresting cell cycle via the modulation of retinoblastoma family of proteins and specified cell cycle inhibitors, and finally inducing cancer cell death by way of apoptosis.
The study, published within the Journal of Cellular Physiology, details findings through Daniela Barone and Letizia Cito, from the study group led by Prof. Antonio Giordano at National Cancer Institute of Naples, Pascale Foundation, CROM. Prof. Antonio Giordano, Director of the Sbarro Institute for Molecular treatment, Temple school and Professor of Pathology and Oncology at the institution of Siena, Italy said, “Our results prompt further assessment of the potential use of specific nutrients not only in the cancer prevention setting but also as a supportive strategy along with conventional therapies.
Barone also added, “Distinct species may exert different effects, in different stages of a certain neoplasm”.
Gastric cancer is the fourth most common type of cancer internationally and has been associated with genetics, Helicobacter pylori illness, and food habits, like consumption of smoked and salty food.
Tomatoes are consumed around the world and are a component of the Mediterranean diet, which is popularly known to decrease the risk for cancer. Various tomato substances have also been analyzed for their ability to counteract tumor progress in experimental techniques, even though few experiences have analyzed the effects of consuming tomatoes in their entirety.