According to new research published in the FASEB journal, “rutin” a natural compound found in mulberries can activate the BAT (brown adipose tissue). BAT enhances our metabolism and helps in losing weight.
“The beneficial effects of rutin on BAT-mediated metabolic improvement have evoked a substantial interest in the potential treatment for obesity and its related diseases, such as diabetes,” mentioned Wan-Zhu Jin, Ph.D., a researcher involved in the work from the Institute of Zoology at the Chinese Academy of Sciences in Beijing, China. “In line with this idea, discovery of more safe and effective BAT activators is desired to deal with obesity and its related diseases.”
Rutin and Obesity
Genetically obese mice with diet-induced obesity were used as models for this research by Jin and his colleagues. Along with the usual diet, they were fed water containing supplemental rutin in the ratio of one milligram per millilitre. Treatment with rutin highly decreased adiposity, increased the energy expenditure and elevated glucose homeostasis in both models. Researchers discovered that rutin stabilizes SIRT1 (NAD-dependent deacetylase sirtuin-1) which leads to the hypoacetylation of PGC1. PGC1 protein is responsible for Tfam transactivation and finally increases mitochondrial number along with UCP1 activity in BAT1.
Rutin acts as a cold mimetic by triggering a SIRT1-PCG1-Tfam signalling cascade. This results in increasing mitochondrial number and UCP1 activity in BAT. Brown-like adipocyte formation is also induced by rutin in subcutaneous adipose tissue in both models.
Rutin in Humans
“Unlike hibernating animals, we humans have only a small spot of brown fat, and yet its importance in human metabolism has only recently come into view,” described Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal. “In this study, the philosophy of ancient Chinese medicine’s exploitation of plant materials has conjoined in the modern era with a very able physiology research team to evoke a promising lead.”
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Written by: Lax Mariappan, Msc